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Nucleic Acids and Molecular Biology pp 184–196Cite as

Adaptability and Specificity in DNA Binding by trp Repressor

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Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 8))

Abstract

Cellular processes such as growth and differentiation are controlled by transcription factors that regulate gene expression by binding to specific DNA sites. Our present understanding of the mechanisms of repression and activation (gene regulation) has evolved from extensive studies on these sequence-specific DNA binding proteins and their DNA targets. A central question in these studies concerns how the protein distinguishes its target site(s) from an enormous background of nonspecific sites. Many regulatory proteins must recognize several closely related but nonidentical sites, or must be able to interact or combine with other factors or subunits that confer new DNA specificities. An emerging picture for the recognition process involves the mutual adjustment, or adaptation, of molecular surfaces to provide the required level of energetic interaction for specific recognition.

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Authors and Affiliations

  1. Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA

    T. A. Lavoie & J. Carey

Authors
  1. T. A. Lavoie
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  2. J. Carey
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Editors and Affiliations

  1. Max-Planck-Institut für Experimentelle Medizin, Hermann-Rein-Straße 3, 37075, Göttingen, Germany

    Fritz Eckstein

  2. Biochemistry Department, University of Dundee, Dundee, DD1 4HN, UK

    David M. J. Lilley

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© 1994 Springer-Verlag Berlin Heidelberg

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Lavoie, T.A., Carey, J. (1994). Adaptability and Specificity in DNA Binding by trp Repressor. In: Eckstein, F., Lilley, D.M.J. (eds) Nucleic Acids and Molecular Biology. Nucleic Acids and Molecular Biology, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78666-2_10

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  • DOI: https://doi.org/10.1007/978-3-642-78666-2_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78668-6

  • Online ISBN: 978-3-642-78666-2

  • eBook Packages: Springer Book Archive

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