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Andere Transducer

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Biosensoren

Part of the book series: Biotechnologie ((BIOTECH))

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Zusammenfassung

Biochemische Reaktionen sind in der Regel deutlich exotherm. Die Bestimmung der Reaktionswärme bietet daher eine universelle Möglichkeit zur Transduktion in einem Biosensor. Die Detektion hängt bei solchen Sensoren nicht vom Verbrauch oder der Entstehung elektroaktiver oder optisch aktiver Verbindungen ab; die Methode ist daher auch unempfindlich gegen optische oder elektrochemische Störungen. Die Enthalpieänderung ist bei vielen Reaktionen groß genug, daß bereits enzymatische Ein-Schritt-Reaktionen ohne Verstärkung zur Detektion ausreichen (Tab. 11.1). Häufig kann durch Kopplung mit einem zweiten Enzym noch eine Folgereaktion genutzt werden, beispielsweise durch die Kombination von Oxidasen (H2O2-Bildung) mit Katalase (H2O2-Spaltung), wobei durch die Aufsummierung beider Reaktionsenthalpien in einfacher Weise eine Signalverstärkung erzielt werden kann.

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Authors and Affiliations

  1. Institute of Biotechnology, Cambridge University, Cambridge, UK

    Dr. Elizabeth A. H. Hall

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  1. Dr. Elizabeth A. H. Hall
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© 1995 Springer-Verlag Berlin Heidelberg

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Hall, E.A.H. (1995). Andere Transducer. In: Biosensoren. Biotechnologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78660-0_11

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  • DOI: https://doi.org/10.1007/978-3-642-78660-0_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-57478-1

  • Online ISBN: 978-3-642-78660-0

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