Developmental Toxicity — Magnitude of the Problem
Human reproduction is a complex process, and can be disturbed in many phases by host as well as environmental factors. It has therefore been difficult to distinguish environmental causes of abnormal development from other factors related to the parents’ innate properties. Among the environmental factors, chemical insult to the conceptus can result in any one or more of the following manifestations of developmental toxicity: Death, structural abnormality, growth alteration, and/or functional deficit. These manifestations encompass a wide array of adverse developmental endpoints, such as spontaneous abortions, stillbirths, malformations, early postnatal mortality, reduced birth weight, mental retardation, sensory loss, and other adverse functional or physical changes that are manifested postnatally (Fed. Reg. 1991).
KeywordsCerebral Palsy Congenital Malformation Perinatal Mortality Intrauterine Growth Retardation Fetal Alcohol Syndrome
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