Transgenic Mouse Models in Chemical Carcinogenesis Studies

  • R. Tennant
Conference paper
Part of the Archives of Toxicology, Supplement 16 book series (TOXICOLOGY, volume 16)

Abstract

Cancer research today faces some important dilemmas in the search for causes of cancer. It is well known that certain environmental factors, such as particular chemicals can be a cause of cancers in humans, but that results derived from humans, as well as experimental models, have shown that there is an important genetic aspect to the disease. The genetic component involves many different genes that influence susceptibility to carcinogens and tumor progression, and other genes that may be mutated by chemicals which initiate carcinogenesis, or genes lose the capacity to regulate cancer cells.

Keywords

Peroxide Acetone Benzol Adenocarcinoma Microbe 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adams JM and Cory S (1991) Transgenic models of tumor development.Science 254:1161–1166.PubMedCrossRefGoogle Scholar
  2. Ashby, J and Tennant RW (1991) Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the US NTP. Mutat. Res. 257:229–306.PubMedGoogle Scholar
  3. Bradley A (1993) Site directed mutagenesis in the mouse. Recent Prog Horm Res 48:237–251.PubMedGoogle Scholar
  4. Brinster RL, Chen HY, Trumbauer M, Senear AW, Warren R and Palmiter RD (1981) Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell 27:223–231.PubMedCrossRefGoogle Scholar
  5. Cardiff RD, Leder A, Kuo A, Pattengale PK and Leder P (1993) Multiple tumor types appear in a transgenic mouse with the RAS oncogene. Am J Path 142:1199–1207.PubMedGoogle Scholar
  6. Fowlis DJ and Balmain A (1993) Oncogenes and tumor suppressor genes in transgenic mouse models of neoplasia. Eur J. Cancer 29A: 638–645.Google Scholar
  7. Gossen J and Viig J (1993) Transgenic mice as model systems for studying gene mutations in vivo. T Pers. Genet 9:27–31.Google Scholar
  8. Hansen L and Tennant R. Focal transgene expression associated with papilloma development in v-Ha-ras transgenic TG.AC mice. Mol Carcinog.Google Scholar
  9. Leder A, Juo A, Cardiff RD, Sinn E and Leder P (1990) v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid. Proc. Natl. Acad. Sci USA 87:9178–9182.PubMedCrossRefGoogle Scholar
  10. Leder A, Pattengale PK, Kuo A, Stewart T and Leder P (1986) Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development. Cell 45:485–495.PubMedCrossRefGoogle Scholar
  11. Muller WJ, Sinn E, Pattengale PK, Wallace R and Leder P (1988) Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell 54:105–115.PubMedCrossRefGoogle Scholar
  12. Sinn E, Muller W, Pattengale P, Tepler I, Wallace R and Leder P (1987) Co-expression of MMTV/v-Ha-ras and MMTV/C-myc genes in transgenic mice: synergistic action of oncogenes in vivo. Cell 49:465–475.PubMedCrossRefGoogle Scholar
  13. Spalding JW, Momma J, Elwell M and Tennant RW (in press) Chemically-induced skin carcinogenesis in a transgenic mouse line (TG.AC) carrying a v-Ha-ras genes. Carcinogenesis, in press, 1993.Google Scholar
  14. Stewart TA, Pattengale PK, and Leder P (1984) Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/Myc fusion genes. Cell 38:627–637.PubMedCrossRefGoogle Scholar
  15. Tennant RW, Rao GA, Russfield A, Seilkop S, Braun AG (1993) Chemical effects in transgenic mice bearing oncogenes expressed in mammary tissue. Carcinogenesis 14:29–35.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • R. Tennant
    • 1
  1. 1.Laboratory of Environmental Carcinogenesis and MutagenesisNational Institute of Environmental Health SciencesResearch Triangle ParkUSA

Personalised recommendations