Transgenic Mouse Models in Chemical Carcinogenesis Studies

  • R. Tennant
Conference paper
Part of the Archives of Toxicology, Supplement 16 book series (TOXICOLOGY, volume 16)


Cancer research today faces some important dilemmas in the search for causes of cancer. It is well known that certain environmental factors, such as particular chemicals can be a cause of cancers in humans, but that results derived from humans, as well as experimental models, have shown that there is an important genetic aspect to the disease. The genetic component involves many different genes that influence susceptibility to carcinogens and tumor progression, and other genes that may be mutated by chemicals which initiate carcinogenesis, or genes lose the capacity to regulate cancer cells.


Transgenic Mouse Transgenic Line Transgenic Mouse Model Mouse Mammary tUmor Virus Skin Papilloma 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • R. Tennant
    • 1
  1. 1.Laboratory of Environmental Carcinogenesis and MutagenesisNational Institute of Environmental Health SciencesResearch Triangle ParkUSA

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