Abstract
The wealth of molecular and genetic data over the past decade has resulted in the overwhelming conclusion that cancer is a genetic disease, and that the clonal expansion of a single normal cell to produce a malignant tumour is a complex process which invoves a number of genetic events. One of the most significant advances in cancer research has been the identification of many of the cellular targets which become altered during the development of neoplasia.
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© 1994 Springer-Verlag Berlin Heidelberg
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Brown, K., Kemp, C., Burns, P., Balmain, A. (1994). Importance of Genetic Alterations in Tumour Development. In: Bolt, H.M., Hellman, B., Dencker, L. (eds) Use of Mechanistic Information in Risk Assessment. Archives of Toxicology, Supplement 16, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78640-2_28
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DOI: https://doi.org/10.1007/978-3-642-78640-2_28
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