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Predicting the toxic dose or concentration. Is there a difference?

  • R. Jochemsen
Conference paper
Part of the Archives of Toxicology, Supplement 16 book series (TOXICOLOGY, volume 16)

Abstract

The ultimate objective of conducting toxicity studies is to be able to effectively treat patients with relative safety. Traditionally, safety margins have been considered to be the ratio between the no observed toxic effect dose levels in animal and the therapeutic dose level. The underlying “believes” of this practice are that toxic effects or absence of them can be extrapolated from animal to man and that effects are related to doses. More recently, the latter has been refined to the hypothesis that effects are related to total exposure to the compound and that exposure is better determined by plasma concentrations than by dose (Collins et al 1990).

Keywords

Safety Margin Diet Study Stabilise Body Weight High Dose Range Gavage Administration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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  2. Collins, JM, Grieshaber, CK, Chabner, BA (1990). Journal of the National Cancer Institute 82: 1321PubMedCrossRefGoogle Scholar
  3. Jochemsen, R, Bazot, D, Brillanceau, MH, Lupart, M (1993) Assessment of drag exposure in rat dietary studies. Xenobiotica (In press)Google Scholar
  4. Monro, A (1992) Contemporary issues in toxicology : what is an appropriate measure of exposure when testing drugs for carcinogenicity in rodents ? Toxicology and Applied Pharmacology 112: 171–181.PubMedCrossRefGoogle Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • R. Jochemsen
    • 1
  1. 1.Institut de Recherches Internationales ServierCourbevoie CedexFrance

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