Abstract
The retinoids form a family of compounds structurally and functionally related to vitamin A (all-trans-retinol). Their name derives from the role of vitamin A in visual function in the vertebrate retina. The natural retinoids are isoprenoid compounds with a six-membered carbocyclic ring and an eleven-carbon side chain (Fig. 1), although many of the synthetic compounds with biological retinoid activity differ somewhat from this basic plan (Sporn and Roberts 1985).
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References
Bailey JS, Siu C-H (1988) Purification and partial characterization of a novel binding protein for retinoic acid from neonatal rat. Proc Natl Acad Sci USA 87:6233–6237
Boylan IF, Gudas L (1991) Overexpression of the cellular retinoic acid binding protein I (CRABP-I) results in a reduction in differentiation-specific gene expression in F9 tera-tocarcinoma cells. J Biol Chem 112:965–979
Chytil F, Ong DE (1987) Intracellular vitamin A-binding proteins. Ann Rev Nutrition 7:321–325
Harrington DD, Newberne PM (1970) Correlation of maternal blood levels of vitamin A at conception and the incidence of hydrocephalus in newborn rabbits: an experimental animal model. Lab Anim Sci 20:675–680
Kistler A (1986) Hypervitaminosis A: side effects of retinoids. Biochem Soc Trans 14:936–939
Kochhar DM (1973) Limb development in mouse embryos. I. Analysis of teratogenic effects of retinoic acid. Teratology 7:289–298
Lammer EJ, Chen DT, Hoar RM, Agnish ND, Benke PJ, Braun JT, Curry CJ, Fernhoff PM, Grix AW, Lott IT, Richard JM, Sun SC (1985) Retinoic acid embryopathy. N Eng J Med 313:837–841
Mahmood R, Flanders KC, Morriss-Kay GM (1992) Interactions between retinoids and TGF ßs in mouse morphogenesis. Development 115:67–74
Makover A, Soprano DR, Wyatt ML, Goodman DS (1989) An in-situ hybridization study of the localization of retinol binding protein and transthyretin messenger RNAs during fetal development in the rat. Differentiation 40:17–25
Morriss GM (1972) Morphogenesis of the malformations induced in rat embryos by maternal hypervitaminosis A. J Anat 113:241–250
Morriss-Kay GM (1993) Retinoic acid and craniofacial development: molecules and morphogenesis. BioEssays 15:9–15
Morriss-Kay GM, Murphy P, Hill R, Davidson D (1991) Effects of retinoic acid excess on expression of Hox-2.9 and Krox-20 and on morphological segmentation of the hindbrain of mouse embryos. EMBO J 10:2985–2995
Morriss-Kay GM, Mahmood R (1992) Morphogenesis-related changes in extracellular matrix induced by retinoic acid. In: Morriss-Kay GM (ed) Retinoids in normal development and teratogenesis. OUP, Oxford, pp 165–180
Napoli J (1993) Biosynthesis and metabolism of retinoic acid: roles of CRBP and CRABP in retinoic acid homeostasis. J Nutr 123:362–366
Newall DR, Ward SJ (1990) Relationship between stage of development and type of malformation in retinoic acid-induced teratogenesis of the rat forelimb. Teratology 42(2):24A
Ong D (1993) Retinoid metabolism during intestinal absorption. J Nutr 123:351–355
O’Toole BA, Fradkin R, Warkany J, Wilson JG, Mann GV (1974) Vitamin A deficiency and reproduction in rhesus monkey. J Nutr 104:1513–1524
Ruberte E, Dollé P, Chambon P, Morriss-Kay G (1991) Retinoic acid receptors and cellular binding proteins: II Their differential pattern of transcription during early morphogenesis in mouse embryos. Development 111:45–60
Sporn MB, Roberts AB (1985) Introduction: what is a retinoid? In: Nugent J, Clark S (eds) Retinoids, differentiation and disease. Ciba Foundation Symposium 113, Pitman, London, pp 1–5
Wessels NK (1970) Mammalian lung development: interactions in formation and morphogenesis of tracheal buds. J Exp Zool 175:455–466
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© 1994 Springer-Verlag Berlin Heidelberg
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Morriss-Kay, G., Ward, S., Sokolova, N. (1994). The Role of Retinoids in Normal Development and Retinoid-Induced Malformations. In: Bolt, H.M., Hellman, B., Dencker, L. (eds) Use of Mechanistic Information in Risk Assessment. Archives of Toxicology, Supplement 16, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78640-2_13
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DOI: https://doi.org/10.1007/978-3-642-78640-2_13
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