Nuclear retinoic acid receptors and regulation of gene expression
Retinoids (vitamin A derivatives) play an important role in vertebrate morphogenesis and cellular differentiation. The mechanism underlying the wide spectrum of effects exerted by retinoids is still poorly understood. However, the discovery in recent years of multiple retinoid nuclear receptors that act as transcriptional trans-regulators, and the diversity of response elements to which they bind to regulate the transcriptional activity of specific sets of target genes, represents a great advance in our understanding of the mechanisms underlying the complexity of retinoid effects.
KeywordsRetinoic Acid Retinoic Acid Receptor Nuclear Receptor Superfamily Retinoic Acid Response Element Nuclear Retinoic Acid Receptor
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