Nuclear retinoic acid receptors and regulation of gene expression

  • E. Ruberte
Conference paper
Part of the Archives of Toxicology, Supplement 16 book series (TOXICOLOGY, volume 16)


Retinoids (vitamin A derivatives) play an important role in vertebrate morphogenesis and cellular differentiation. The mechanism underlying the wide spectrum of effects exerted by retinoids is still poorly understood. However, the discovery in recent years of multiple retinoid nuclear receptors that act as transcriptional trans-regulators, and the diversity of response elements to which they bind to regulate the transcriptional activity of specific sets of target genes, represents a great advance in our understanding of the mechanisms underlying the complexity of retinoid effects.


Retinoic Acid Retinoic Acid Receptor Nuclear Receptor Superfamily Retinoic Acid Response Element Nuclear Retinoic Acid Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • E. Ruberte
    • 1
  1. 1.Department of Human AnatomyUniversity of OxfordOxfordUK

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