Cardiac Transplantation for Ischaemic Heart Disease

  • M. Yacoub


Coronary heart disease is one of the commonest causes of morbidity and mortality, particularly in the Western world. Although there have been efforts aimed at prevention, early diagnosis as well as medical and surgical treatment of the disease, these have been only relatively effective. A significant number of patients present with severe heart failure or other manifestations of the disease that are refractory to conventional treatment (e.g., bypass graft failure, unsuitable anatomy). The only effective therapy for these patients is cardiac transplantation. Much experience has been gained with this form of therapy in coronary heart disease, with ischaemic heart disease constituting the commonest indication for cardiac transplantation in most centres [1, 2]. This has resulted in a progressive accumulation of knowledge, which is now sufficient to guide rational decision making in the majority of patients. There are, however, several areas which require further research.


Acute Rejection Ischaemic Heart Disease Cardiac Transplantation Mycophenolate Mofetil Donor Heart 
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© Springer-Verlag Berlin Heidelberg 1994

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  • M. Yacoub

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