Abstract
Coronary heart disease is one of the commonest causes of morbidity and mortality, particularly in the Western world. Although there have been efforts aimed at prevention, early diagnosis as well as medical and surgical treatment of the disease, these have been only relatively effective. A significant number of patients present with severe heart failure or other manifestations of the disease that are refractory to conventional treatment (e.g., bypass graft failure, unsuitable anatomy). The only effective therapy for these patients is cardiac transplantation. Much experience has been gained with this form of therapy in coronary heart disease, with ischaemic heart disease constituting the commonest indication for cardiac transplantation in most centres [1, 2]. This has resulted in a progressive accumulation of knowledge, which is now sufficient to guide rational decision making in the majority of patients. There are, however, several areas which require further research.
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References
Yacoub M (1987) The place of heart transplantation: the British experience. Eur Heart J 8[Suppl l]: 37–38.
Kriett JM, Kaye MP (1990) The registry of the International Society of Heart Transplantation: seventh official report. J Heart Transplant 9: 223.
Rahimtoola S (1989) Hibernating myocardium. Am Heart J 117: 211–221.
Bolli R (1993) Myocardial stunning in man. Circulation 86: 1671–1691.
Ferrari R, La Canna G, Giubbini R, Pardini A, Coletti G, Berra P, Alfresi O (1994) Hibernating myocardium. Annu Cardiac Surg 7: 28.
Ross J Jr (1991) Myocardial perfusion — contraction matching: implications for coronary heart disease and hibernation. Circulation 83: 4076–4082.
Bristow JD, Arai AE, Ansclone CG, Pantely GA (1991) Response to myocardial ischaemia as a regulated process. Circulation 84: 2580–2587.
Marban (1991) Myocardial stunning and hibernation: the physiology behind the collequalisms. Circulation 83: 681–688.
Rahimtoola SH (1985) A perspective on the three large multicenter randomised clinical trials of coronary bypass surgery for chronic stable angina. Circulation 72[Suppl V]: 123–125.
Califf RM, Harrel FE, Lee KL, Rankin JS, Mark DB, Halten MA, Muhlbaier LH, Wichsler AS, Jones R, Oldham HN Jr, Pryor DB (1988) Changing efficacy of coronary revascularisation: implications for patient selection. Circulation 78[Suppl I]: 185–191.
Ridley PD, Khaghani A, Musumeci F, Favaloro R, Akl ES, Banner NR, Mitchell AG, Yacoub MB (1992) Heterotopic heart transplantation and recipient heart operation in ischaemic heart disease. Ann Thor Surg 54: 333–337.
De-Silva R, Camici PG (1994) Hibernating myocardium definition and detection by positron emission tomography. Annu Cardiac Surg 7: 33–40.
Cigarroa CG, de Fillipi CR, Buckner B, Alvarez LG, Wait MA, Grayburn PA (1993) Dobutamine stress echocardiography identifies hibernating myocardium and predicts recovery of left ventricular function after coronary revascularisation. Circulation 88: 430–436.
Dilsizian V, Bonow RO (1993) Current diagnostic techniques of assessing myocardial viability in patients with hibernating myocardium. Circulation 87: 1–20.
Bonow RO, Berman DS, Gibbons RJ, Johnson LL, Rumberger JA, Schwarger M, Wackers FJT (1991) Cardiac positron emission tomography. A report for health professionals from the committee on advanced cardiac imaging and technology of the council on clinical cardiology. American Heart Association. Circulation 84: 447–454.
Eilzman D, Al-Aouar Z, Kanter BL, Von Dahl J, Kirsh M, Deeb GM, Schwarzer M (1992) Clinical outcome of patients with advanced coronary artery disease after viability studies with positron emission tomography. J Am Coll Cardiol 20: 559–565.
Bonow RO, Dilsizian V, Cuocolo A, Bacharach SL (1991) Identification of viable myocardium in patients with chronic coronary artery disease and left ventricular dysfunction. Comparison of thalium scintography with re-injection and PET imaging with 18F-Fluorodeoxyn glucose. Circulation 83: 26–37.
Mancini DM, Bisen H, Kussmaul W, Mull R, Edmonds LH, Wilson JR (1991) Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure. Circulation 83: 778–786.
Mudge GH, Goldstein S, Addorizio LJ, Caplan A, Mancini D, Levine B, Rilsch MR Jr (1993) Task force 3: Recipient guidelines/p terisation. JACC 22: 21–31.
Borer JS (1989) Prognostication strategies in heart failure and valvular heart diseases: Current concepts and their support. In: Yacoub M (ed) Annual of cardiac surgery. Current Science, Philadelphia, pp 115–124.
Cohn JN, Rector TJ (1988) Prognosis of congestive heart failure and predictors of mortality. Am J Cardiol 62[Suppl]: 25A–30A.
Stevenson LW, Tillisch JH, Hamilton M, Luu M, Chelimsky-Fallick C, Moriguchi J, Waiden J (1990) Importance of haemodynamic response to therapy in predicting survival with ejection fraction ≤20% secondary to ischaemic or nonischaemic dilated cardiomyopathy. Am J Cardiol 66: 1348–1354.
Klein H, Trapper HJ, Feigirth HG, Nisam S (1993) Prospective studies evaluating prophylactic ICD therapy for high risk patients with coronary artery disease. PACE 16: 564–576.
Rokitansky A, Walner E (1989) Total artificial heart and assist devices as a bridge to transplantation. Int J Artif Organs 12: 77–84.
Hill JD (1989) Bridging to cardiac transplantation. Ann Thorac Surg 47: 167–171.
Cass MH, Brock R (1959) Heart excision and replacement. Guy’s Hospital Reports 108: 205–290.
Lower RR, Shumway NE (1960) Studies on orthotopic transplantation. Surg Forum 11: 18.
Yacoub MH, Mankad P, Ledingham S (1990) Donor procurement and surgical techniques for cardiac transplantation. Semin Thorac Cardiovasc Surg 2: 153–161.
Barnard CN, Losman JG (1975) Left ventricular bypass. S Afr Med J 49: 303.
Galbraith TA, Yacoub M (1987) Heterotopic heart transplantation: operative technique and results in heart transplantation. In: Myerowitz DP (ed) Futura, Mount Kisco, NY, pp 155–168.
Akasaka T, Lythal D, Cheng A, Yoshida K, Yoshikawa J, Mitchell A, Yacoub M (1989) Continuous aortic regurgitation in severely dysfunctional native hearts after heterotopic cardiac transplantation. Am J Cardiol 63:(20) 1483–1488.
Thurgood JM, Cowell R, Paul V, Kalsi K, Seymour A-M, Ilsley C, Mitchell A, Khaghani A, Yacoub MH (1994) Haemodynamic and metabolic effects of paced linkage following heterotopic cardiac transplantation. Circulation (in press).
Lindholm A (1991) Therapeutic monitoring of cyclosporin: an update. Em J Clin Pharmacol 41: 273–283.
Yacoub M, Alivazatos P, Khaghani A, Mitchell A (1985) The use of cyclosporin, azathioprine and antilymphocyte globulin with or without low dose steroids for immunosuppression of cardiac transplant patients. Transplant Proc XVII(I): 221.
Renlund DG, O’Connell JB, Bristow MR (1990) Strategies of immunosuppression in cardiac transplantation. Semin Thorac Cardiovasc Surg 2: 181–188.
Swinnen LJ, Costanzo-Nordin MR, Tischer SG, O’Sullivan EJ, Johnson MR, Heroux AL, Dizikes GJ, Pifarre R, Fisher RI (1990) Increased incidence of lymphoproliferative disorder after immunosuppression with the monoclonal antibody OKT3 in cardiac-transplant recipients. N Engl J Med 323: 1723.
Ghada M, Eadon H, Leaver N, Yacoub M (1994) The use of Neoral in heart transplant recipients. Transplant Proc (in press).
Lindholm A, Kahan BD (1993) Influence of cyclosporine pharmacokinetics, trough concentrations and AUC monitoring on outcome after kidney transplantation. Clin Pharmacol Thor 54: 205–218.
Schreiber SL, Crabtree GR (1992) The mechanism of action of Cyclosporine A and FK 506. Immunol Today 13: 136–142.
Allison AC, Engui EM, Sallinger HW (1993) Mycophenolate Mofetil (RS-61443): mechanism of action and effects in transplantation. Transplant Rev 7: 129–139.
Billingham RE, Brent L, Medawar PB (1953) Actively acquired tolerance of foreign cells. Nature 172: 603.
Yacoub M (1994) Transplantation in the third millenium. In: Newsom-Davies J, Weatherall D (eds) Health policy and technological innovation. Chapman and Hall, London, pp 37–48.
Billingham ME (1982) Diagnosis of cardiac rejection by endomyocardial biopsy. J Heart Transplant 1: 25–30.
Valantine HA, Hunt SA (1993) Clinical and non-invasive methods of diagnosing rejection after heart transplantation. In: Rose M, Yacoub MH (eds) Immunology of heart and lung transplantation. Edward Arnold, London, pp 219–231.
Lythal D, Gibson D, Swanson K, Mitchell A, Ilsley C, Yacoub M (1990) Quantitative analysis of myocardial echo amplitude-a useful marker of cardiac rejection. Circulation 80[Suppl II]: 677.
Yacoub M, Festenstein H, Doyle P, et al. (1987) The influence of HLA matching in cardiac allograft recipients receiving cyclosporin and azathioprine. Transplant Proc 19: 2487–2489.
Opelz G, Wujcoak T (1994) The influence of HLA compatibility on graft survival after heart transplantation. N Engl J Med 330(12): 816–819.
Morris PJ (1994) HLA matching and cardiac transplantation. N Engl J Med 330(12): 857–858.
Borow K, Newmann A, Arensman F, Yacoub M (1985) Left ventricular contractility and contractile reserve in humans after cardiac transplantation. Circulation 71(5): 866–872.
Banner NR, Yacoub MH (1990) Physiology of the orthotopic cardiac transplant recipient. Semin Thorac Cardiovasc Surg 2: 259.
Banner NR, Lloyd MH, Hamilton RD et al. (1989) Cardiopulmonary response to dynamic exercise after heart and heart-lung transplantation. Br Heart J 61: 215–223.
Singer D, Banner N, Cox A, Patel N, Burden M, Buckley M, MacGregor G, Yacoub M (1990) Response to dynamic exercise in cardiac transplant recipients: implications for control of the sodium regulatory hormone atrial naturellic peptide. Clin Sci 78(2): 159–163.
Wharton D, Polak J, Gordon L, Banner N, Springall D, Rose M, Khaghani A, Wallwork J, Yacoub M (1990) Immunohistochemical dimensions of human cardiac innervation before and after transplantation. Circ Res 66(4): 900–912.
Wilson RF, Christensen BV, Olivari MT, Simon A, White CW, Laxson DD (1991) Evidence for structural sympathetic reinnervation after orthotopic cardiac transplantation in humans. Circulation 83(4): 1210–1220.
Banner NR, Khaghani A, Mitchell AG, Radley-Smith R, Lockwood P, Lloyd MH, Yacoub M (1987) Haemodynamics and lung functions one year after combined heart lung transplantation. Br Heart J 57: 87 (Abstract).
Dummer JF (1990) Infections complications of transplantation. In: Thompson ME (ed) Cardiac transplantation. Davis, Philadelphia, pp 163–178.
Ozdogan E, Banner N, Fitzgerald M et al. (1990) Factors influencing the development of hypertension following cardiac transplantation. J Heart Transplant 9: 548.
Thomas JA, Crawford DH (1993) Biology of lymphoproliferative disease in transplant patients. In: Rose M, Yacoub M (eds) Immunology of heart and lung transplantation. Edward Arnold, London, pp 243–260.
Sheil AGR (1988) Cancer in dialysis and transplant patients. In: Morris P (ed) Transplantation: principles and practice. Saunders, Philadelphia, pp 603–618.
Yacoub M, Rose M (1994) Accelerated coronary sclerosis. Annu Cardiac Surg 7: 80–89.
Barbir M, Kushwaha S, Hunt B, MacKenna A, Thompson GR, Mitchell A, Robinson D, Yacoub M (1992) Lipoprotein (a) and accelerated coronary arterial disease in cardiac transplant recipients. Lancet 340: 1500–1502.
Drinkwater D, Rudis E, Laks H, Marino J, Stein D, Ardebali A, Aharon A (1994) UW versus Stanford cardioplegia and the development of allograft coronary arterial vasculopathy. J Heart Lung Transplant 13(1-2): S47 (Abstract).
Mankad PS, Chester AH, Yacoub MH (1991) Role of potassium concentration in cardioplegic solutions in mediating endothelial damage. Ann Thorac Surg 51(1): 89–93.
Dunn MJ, Crisp SJ, Rose ML, Taylor PM, Yacoub MH (1991) Detection of anti-endothelial antibodies by Western blotting-positive correlation with coronary artery disease after cardiac transplantation. Lancet 339: 1566.
Barbir M, Bowker T, Ludman P, Mitchell A, Wood D, Yacoub M (1994) Ultrafast CT scanning for the detection of coronary disease in cardiac transplant recipients. Am J Cardiol (in press).
Kavanagh T, Yacoub M, Mertens D, Kennedy J, Campbell R, Sawyer P (1988) Cardiorespiratory responses to exercise training after orthotopic cardiac transplantation. Circulation 77: 162–171.
Stratton JR, Kemp GJ, Daly RC, Yacoub M (1994) Effects of cardiac transplantation on bioenergetic abnormalities of skeletal muscle in congetive heart failure. Circulation (in press).
Kaye MP (1993) The Registry of the International Society for Heart and Lung Transplantation: Tenth Official Report — 1993. J Heart Lung Transplant 12(4): 543.
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Yacoub, M. (1994). Cardiac Transplantation for Ischaemic Heart Disease. In: Lüscher, T.F., Turina, M., Braunwald, E. (eds) Coronary Artery Graft Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78637-2_23
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DOI: https://doi.org/10.1007/978-3-642-78637-2_23
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