Abstract
Graft occlusion remains the most important adverse event after coronary artery bypass graft (CABG) surgery. Occlusion rates increase from 10%– 15% per distal anastomosis in the first month to approximately 16%–26% at 1 year, averaging 37% at 5–7 years and 55% at 10–12 years [1, 2]. A recent study reported graft disease in 8% at 1 year, 38% at 5 years, and 75% at 10 years postoperatively [3]. The pathogenesis of vein graft occlusion appears to have some similarities with the development and progression of atherosclerosis, which is discussed by Jang and Fuster (this volume). Drug therapy should therefore be aimed at intervening in this pathogenesis. Since platelet deposition is an early factor in the occlusive process, platelet inhibitors play an important role here. Anticoagulants, on the other hand, are potent drugs to prevent arterial thrombus formation. These two groups of drugs have therefore been used during the past decade to prevent vein graft occlusion.
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© 1994 Springer-Verlag Berlin Heidelberg
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Pfisterer, M. (1994). Anticoagulants and Antiplatelet Drugs to Prevent Aortocoronary Vein Graft Occlusion. In: Lüscher, T.F., Turina, M., Braunwald, E. (eds) Coronary Artery Graft Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78637-2_18
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DOI: https://doi.org/10.1007/978-3-642-78637-2_18
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