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Antiplatelet Drugs

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Coronary Artery Graft Disease

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Abstract

Thrombus and platelet deposition in vein grafts begins intraoperatively as soon as blood begins to flow through the graft [1]. This knowledge led to antithrombotic therapy being started perioperatively and to the first convincing platelet inhibitor trial in coronary bypass graft operations [2, 3]. Prior studies had started the same therapy several days after operation when thrombus had already formed, and thus they were unsuccessful [4]. In the first several months after operation, occlusion is related to thrombosis that is, in part, due to vein graft injury, technical problems, and associated coronary artery disease with small coronary arteries and low vein-graft blood flow [1-3, 5-7]. Asymptomatic mural thrombosis within vein grafts appears considerable, is probably underestimated at angiography, and is only recognized in its most extensive form (Fig. 1).

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Authors
  1. J. H. Chesebro
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  2. B. J. Meyer
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  3. A. Fernandez-Ortiz
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  4. I. K. Jang
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  5. V. Fuster
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Editors and Affiliations

  1. Abteilung Kardiologie, Inselspital, 3010, Bern, Switzerland

    Thomas F. Lüscher

  2. Herz-Gefäßchirurgie, Universitätsspital, 8091, Zürich, Switzerland

    Marko Turina

  3. Department of Medicine, Harvard University and Brigham and Women’s Hospital, Boston, MA, 02115-6195, USA

    Eugene Braunwald

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© 1994 Springer-Verlag Berlin Heidelberg

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Chesebro, J.H., Meyer, B.J., Fernandez-Ortiz, A., Jang, I.K., Fuster, V. (1994). Antiplatelet Drugs. In: Lüscher, T.F., Turina, M., Braunwald, E. (eds) Coronary Artery Graft Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78637-2_17

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  • DOI: https://doi.org/10.1007/978-3-642-78637-2_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78639-6

  • Online ISBN: 978-3-642-78637-2

  • eBook Packages: Springer Book Archive

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