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Molecular and Genetic Determinants of the Listeria monocytogenes Infectious Process

  • Chapter
Bacterial Pathogenesis of Plants and Animals

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 192))

Abstract

Listeria monocytogenes was first characterized in 1926 following an outbreak of listeriosis in laboratory animals (MURRAY et al. 1926). However, it was not until the 1980s that an unambiguous link was established between the human disease and the consumption of Listeria-contaminated foodstuffs (SCHLECH et al. 1983). Immunosuppressed individuals, pregnant women, foetuses and neonates are most susceptible to Listeria infection. Human listeriosis is characterized by a high mortality rate, with clinical features including meningitis or meningo-encephalitis, septicemia, abortion, and perinatal infections (GRAY and KILLINGER 1966). If diagnosed early, listeriosis can be successfully treated by the administration of high doses of antibiotics, most frequently ampicillin or penicillin, either alone or in combination with aminoglycosides.

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  1. Unité des Interactions Bacteria-Cellules, CNRS URA 1300, Institut Pasteur, 28 rue du Dr Roux, 75724, Paris Cedex 15, France

    B. Sheehan, C. Kocks, S. Dramsi, E. Gouin, A. D. Klarsfeld, J. Mengaud & P. Cossart

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  1. B. Sheehan
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  2. C. Kocks
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  3. S. Dramsi
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  4. E. Gouin
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  5. A. D. Klarsfeld
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  6. J. Mengaud
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  1. Max-Delbrück-Laboratory, Carl-von-Linné-Weg 10, 50829, Cologne, Germany

    Jeffery L. Dangl

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Sheehan, B. et al. (1994). Molecular and Genetic Determinants of the Listeria monocytogenes Infectious Process. In: Dangl, J.L. (eds) Bacterial Pathogenesis of Plants and Animals. Current Topics in Microbiology and Immunology, vol 192. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78624-2_9

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  • DOI: https://doi.org/10.1007/978-3-642-78624-2_9

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