Shigella flexneri: Genetics of Entry and intercellular Dissemination in Epithelial Cells

  • C. Parsot
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 192)


A century ago, Shiga isolated the etiologic agent of bacillary dysentery (SHIGA 1898) . The genus Shigella is now divided into four species, S. boydii, S. dyseriteriae, S. flexneri, and S. sonnei. Shigellosis, whose clinical signs range from mild diarrhea to severe dysentery with blood, mucus, and pus in the stool, remains endemic throughout the world. Epidemiological studies indicate that Shigella is transmitted by the fecal-oral route and sometimes by contaminated food (WHARTON et al. 1990). Shigella are highly infectious organisms for humans, since only a few hundred bacteria administered orally caused disease in 50% of volunteers (DUPONT et al. 1989).


Shiga Toxin Shigella Flexneri Virulence Plasmid Shigella Dysenteriae Shigella Strain 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • C. Parsot
    • 1
  1. 1.Unité de Pathogénie Microbienne Moléculaire et Unité INSERM 199Institut PasteurParis CedexFrance

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