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Borna Disease pp 103-130 | Cite as

Human Infections with Borna Disease Virus and Potential Pathogenic Implications

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 190)

Abstract

Borna disease (BD) has been described as an infectious progressive type of nonpurulent encephalomyelitis in horses and sheep (Nicolau and Galloway 1928; Seifried and Spatz 1930; Zwickgt 1939; Gosztonyi; and Ludwig 1984b; Ludwig et al. 1985). It is known to occur sporadically in endemic areas in Central Europe (mainly Eastern and Southern Germany) (Zwick 1939; Dürrwald 1993). In a broad variety of species, from chicken to nonhuman primates, inoculation of brain homogenates from infected animals results in clinical manifestations that range from acute fatal neurologic disease to chronic subtle neurobehavioral syndromes (Ludwig et al. 1985, 1988). Immune-mediated mechanisms (leading to inflammatory lesions) have been shown to play a major role during the development of natural (Gosztonyi and Ludwig 1984b) and experimental disease (rat) (Hirano et al. 1983; Narayan et al. 1983 a, b; Richt et al. 1989, 1990; Stitz et al. 1989). In several species, including the newborn rat (Hirano et al. 1983; Narayan et al. 1983a), the mouse (Kao et al. 1984), and the hamster (Anzil et al. 1973; Ludwig et al. 1993), persistent infection has been established that presents as learning deficiencies (Bode et al. 1989; Dittrich et al. 1989). Inapparent or subtle clinical courses have also been observed in naturally infected horses (Ihlenburg and Brehmer 1964; Lange et al. 1987; Ludwig et al., unpublished) and sheep (Matthias 1954). The broad host range and variable clinical presentations led to consideration of the possibility that humans might be infected with BDV (Amsterdam et al. 1987).

Keywords

Chronic Fatigue Syndrome Human Infection Madin Darby Canine Kidney Infected Horse Paranoid Psychosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Amsterdam JD, Winokur A, Dyson, W, Herzog S, Gonzalez F, Rott R, Koprowski H (1985) Borna disease virus: a possible etiologic factor in human affective disorders? Arch Gen Psychiatry 42: 1093–1096PubMedGoogle Scholar
  2. Amsterdam JD, Winokur A, Dyson W, Herzog S, Gonzalez F, Rott R, Koprowski H (1987) Demonstration of antibodies to Borna disease virus in patients with affective disorders. In: Kurstak E, Lipowski ZJ, Morozov PV (eds) Viruses, immunity and mental disorders. Plenum Medical, New York, pp 179–185Google Scholar
  3. Amsterdam JD, Ludwig H, Riegel S, Bode L, Koprowski H (1988) Borna disease virus in psychiatric patients and healthy volunteers (abstract). 2nd world conference on viruses, immunity and mental health, 4–7 Oct 1988. Montreal, CanadaGoogle Scholar
  4. Anzil AP, Blinzinger K, Mayr A (1973) Persistent Borna virus infection in adult hamsters. Arch Gesamte Virusforsch 40: 52–57PubMedCrossRefGoogle Scholar
  5. Bause-Niedrig I, Pauli G, Ludwig H (1991) Borna disease virus-specific antigens: two different proteins identified by monoclonal antibodies. Vet Immunol Immunopathol 27: 293–301PubMedCrossRefGoogle Scholar
  6. Bechter K, Herzog S (1990) Über Beziehungen der Bornaschen Krankheit zu endogenen Psychosen. In: Kaschka WP, Aschauer HN (eds) Psychoimmunologie. Thieme, Stuttgart, pp 133–141Google Scholar
  7. Bechter K, Herzog S, Fleischer B, Schüttler R, Rott R (1987) Kernspintomographische Befunde bei psychiatrischen Patienten mit und ohne Serum-Antikörper gegen das Virus der Bornaschen Krankheit. Nervenarzt 58: 617–624PubMedGoogle Scholar
  8. Bechter K, Herzog S, Schüttler R, Rott R (1989a) MRI in psychiatric patients with serum antibodies against Borna disease virus. Psychiat Res 29: 281–282CrossRefGoogle Scholar
  9. Bechter K, Herzog S, Schüttler R, Rott R (1989b) Die Bornasche Krankheit-wahrscheinlich auch eine menschliche Krankheit: neue Ergebnisse. In: Saletu B (ed) Biologische Psychiatrie. Thieme, Stuttgart, pp 17–21Google Scholar
  10. Bechter K, Schüttler R, Herzog S (1992a) Case of neurological and behavioral abnormalities: due to Borna disease virus encephalitis? Psychiatry Res 42: 193–196PubMedCrossRefGoogle Scholar
  11. Bechter K, Schüttler R, Herzog S (1992b) Borna disease virus: possible causal agent in psychiatric and neurological disorders in two families. Psychiatry Res 42: 291–294PubMedCrossRefGoogle Scholar
  12. Bechter K, Herzog S, Schüttler R (1992c) Possible significance of Borna diesease for humans. Neurol Psychiatr Brain Res 1: 23–29Google Scholar
  13. Bode L, Ludwig H (1989) Borna disease virus infections and immune response in primates and man. In: Proceedings of the 3rd annual symposium of the European Society of Veterinary Neurology, Bern, Switzerland, pp 89–90Google Scholar
  14. Bode L, Riegel S (1988) Immune response to Borna disease (BD) virus infections in animals and man (abstract). 2nd world conference on viruses, immunity and mental health, 4–7 Oct 1988; Montreal, CanadaGoogle Scholar
  15. Bode L, Riegel S, Ludwig H, Amsterdam JD, Lange W, Koprowski H (1988) Borna disease virus-specific antibodies in patients with HIV infection and with mental disorders. Lancet ii: 689CrossRefGoogle Scholar
  16. Bode L, Dittrich W, Ludwig H (1989) Lernschwäche bei klinisch gesunden Ratten nach Bornavirus-lnfektion. Zentralbl Bakteriol 271: 394Google Scholar
  17. Bode L, Riegel S, Czech G, Lange W, Ludwig H (1990a) Increased incidence of Borna disease virus infection in chronically diseased patients. In: VINth international congress of virology, abstracts, Berlin, Germany, p 138Google Scholar
  18. Bode L, Riegel S, Reckwald P, Ludwig H (1990b) Improved and rapid serodiagnosis of Borna disease virus infections in animals and man. In : VIIIth international congress of virology, abstracts, Berlin, Germany, p 302Google Scholar
  19. Bode L, Querfurth H, Ferszt R, Gosztonyi G, Rigas N, Czech G, Ludwig H (1991) Antibodies to Borna disease virus are four times as frequent in depressives as in controls. In: Wissenschaftswoche 1991, Forschungsprojekte am Klinikum Steglitz, Freie Universität Berlin, pp 269–271Google Scholar
  20. Bode L, Riegel S, Lange W, Ludwig H (1992a) Human infections with Borna disease virus: sero-prevalence in patients with chronic diseases and healthy individuals. J Med Virol 36: 309–315PubMedCrossRefGoogle Scholar
  21. Bode L, Czech G, Ferszt R, Ludwig H (1992b) Bornavirus-lnfektion beim Menschen: eine neue Zoonose? In: Böhm R (ed) Bericht des 4. Hohenheimer Seminars “Aktuelle Zoonosen”. Deutsche Veterinärmedizinische Gesellschaft, Schriftenreihe, Giessen (ISBN 3–924851-68–9), pp 138–147Google Scholar
  22. Bode L, Komaroff AL, Ludwig H (1992c) No serologic evidence of Borna disease virus in patients with chronic fatigue syndrome. Clin Infect Dis 15: 1049PubMedCrossRefGoogle Scholar
  23. Bode L, Ferszt R, Czech G (1993a) Borna disease virus infection and affective disorders in man. Arch Virol Suppl 7: 159–167PubMedGoogle Scholar
  24. Bode L, Ferszt R, Ludwig H (1993b) Ist ein “neues” Virus an affektiven Psychosen beteiligt? Hohe Prävalenz von Borna disease Virus (BDV) Antikörpern in psychiatrischen Patienten. In: 2. Deutscher Kongress für Infektions- und Tropenmedizin, abstracts, Berlin, Germany, p 43Google Scholar
  25. Bode L, Steinbach F, Ludwig H (1994) A novel marker for Borna disease virus infection. Lancet 343: 297–298PubMedCrossRefGoogle Scholar
  26. Böyum A (1968) Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 21 [Suppl 97]: 77–89Google Scholar
  27. Briese T, de la Torre JC, Lewis A, Ludwig H, Lipkin Wl (1992) Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells. Proc Natl Acad Sci USA 89: 11486–11489PubMedCrossRefGoogle Scholar
  28. Carbone KM, Duchala CS, Griffin JW, Kincaid AL, Narayan O (1987) Pathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and determinant for disease incubation. J Virol 61: 3431–3440PubMedGoogle Scholar
  29. Carbone KM, Moench T, Lipkin Wl (1991) Borna disease virus replicates in astrocytes, Schwann cells and ependymal cells in persistently infected rats: location of viral genomic and messenger RNAs by in situ hybridization. J Neuropathol Exp Neurol 50: 205–214PubMedCrossRefGoogle Scholar
  30. Carter NP (1990) Measurement of cellular subsets using antibodies. In: Ormerod MG (ed) Flow cytometry, a practical approach. IRL Press at Oxford University Press, Oxford, pp 45–75Google Scholar
  31. Cervos-Navarro J, Roggendorf W, Ludwig H, Stitz L (1981) Die Borna-Krankheit beim Affen unter Berücksichtigung der encephalitischen Reaktion. Verh Dtsch Ges Pathol 65: 208–212PubMedGoogle Scholar
  32. Crow TJ (1991) The virogene hypothesis of psychosis: current status. In: Kurstak E (ed) Psychiatry and biological factors. Plenum, New York, pp 9–22Google Scholar
  33. De la Torre JC, Carbone KM, Lipkin Wl (1990) Molecular characterization of the Borna Disease agent. Virology 179: 853–856PubMedCrossRefGoogle Scholar
  34. Dittrich W, Bode L, Ludwig H, Kao M, Schneider K (1989) Learning deficiencies in Borna disease virus- infected but clinically healthy rats. Biol Psychiatry 26: 818–828PubMedCrossRefGoogle Scholar
  35. Dürrwald R (1993) Die natürliche Borna-Virus-Infektion der Einhufer und Schafe: Untersuchungen zur Epidemiologie, zu neueren diagnostischen Methoden (ELISA, PCR) und zur Antikörperkinetik bei Pferden nach Vakzination mit Lebendimpfstoff. Inagu dissertation, Fachbereich Veterinärmedizin, Freie Universität Berlin, 156 pagesGoogle Scholar
  36. Fu ZF, Amsterdam JD, Kao M, Shankar V, Koprowski H, Dietzschold B (1993) Detection of Borna disease virus-reactive antibodies from patients with affective disorders by Western immunoblot technique. J Affect Disord 27: 61–68PubMedCrossRefGoogle Scholar
  37. Goldfarb LG, Gajdusek DC (1992) Viliuisk encephalomyelitis in the lakut people of Siberia. Brain 115: 961–978PubMedCrossRefGoogle Scholar
  38. Gosztonyi G, Ludwig H (1984a) Neurotransmitter receptors and viral neurotropism. Neuropsychiatr Clin 3: 107–114Google Scholar
  39. Gosztonyi G, Ludwig H (1984b) Borna disease of horses: an immunohistological and virological study of naturally infected animals. Acta Neuropathol (Berl) 64: 213–221CrossRefGoogle Scholar
  40. Gosztonyi G, Briese T, Bode L, Lipkin Wl, Ludwig H (1991) Immunohistological and molecular detection of Borna disease virus-specific structures in the brain. Clin Neuropathol 10: 262Google Scholar
  41. Gosztonyi G, Dietzschold B, Kao M, Rupprecht CE, Ludwig H, Koprowski H (1993) Rabies and Borna disease: a comparative pathogenetic study of two neurovirulent agents. Lab Invest 68: 285–295PubMedGoogle Scholar
  42. Haas B, Becht H, Rott R (1986) Purification and properties of an intranuclear virus-specific antigen from tissue infected with Borna disease virus. J Gen Virol 67: 235–241PubMedCrossRefGoogle Scholar
  43. Hirano N, Kao M, Ludwig H (1983) Persistent, tolerant or subacute infection in Borna disease virus infected rats. J Gen Virol 64: 1521–1530PubMedCrossRefGoogle Scholar
  44. Ihlenburg H, Brehmer H (1964) Beitrag zur latenten Borna-Erkrankung des Pferdes. Monatsh Vet Med 19: 463–465Google Scholar
  45. Kao M, Gosztonyi G, Ludwig H (1983) Obesity syndrome in Borna disease virus infected rats. Zentralbl Bakteriol Mikrobiol Hyg [A] 255: 173Google Scholar
  46. Kao M, Ludwig H, Gosztonyi G (1984) Adaptation of Borna disease virus to the mouse. J Gen Virol 65: 1845–1849PubMedCrossRefGoogle Scholar
  47. Kao M, Hamir AN, Rupprecht CE, Fu ZF, Shankar V, Koprowski H, Dietzschold B (1993) Detection of antibodies against Borna disease virus in sera and cerebrospinal fluid of horses in the USA. Vet Rec 132: 241–244PubMedCrossRefGoogle Scholar
  48. Komaroff AL, Buchwald D (1991) Symptoms and signs of chronic fatigue syndrome. Rev Infect Dis 13 [Suppl 1]: 8–11CrossRefGoogle Scholar
  49. Krey HF, Ludwig H, Rott R (1979) Spread of infectious virus along the optic nerve into the retina in Borna disease virus-infected rabbits. Arch Virol 61: 283–288PubMedCrossRefGoogle Scholar
  50. Lange H, Herzog S, Herbst W, Schliesser T (1987) Seroepidemiologische Untersuchungen zur Bornaschen Krankheit der Pferde. Tierarztl Umschau 42: 938–946Google Scholar
  51. Lipkin Wl, Carbone KM, Wilson MC, Duchala CS, Narayan O, Oldstone MBA (1988) Neurotransmitter abnormalities in Borna disease. Brain Res 475: 366–370PubMedCrossRefGoogle Scholar
  52. Lipkin Wl, Travis GH, Carbone KM, Wilson MC (1990) Isolation and characterization of Borna disease agent cDNA clones. Proc Natl Acad Sci USA 87: 4184–4188PubMedCrossRefGoogle Scholar
  53. Lipkin Wl, Briese T, De la Torre JC (1992) Borna disease virus: molcular analysis of a neurotropic infectious agent (Mini-review). Microb Pathog 13: 167–170PubMedCrossRefGoogle Scholar
  54. Ludwig H, Becht H (1977) Borna disease - a summary of our present knowledge. In: ter Meulen V, Katz M (eds) Slow virus infections of the central nervous system, Springer, New York, Heidelberg, Berlin, pp 75–83Google Scholar
  55. Ludwig H, Thein P (1977) Demonstration of specific antibodies in the central nervous system of horses naturally infected with Borna disease virus. Med Microbiol Immunol 163: 215–226PubMedCrossRefGoogle Scholar
  56. Ludwig H, Koester V, Pauli G, Rott R (1977) The cerebrospinal fluid of rabbits infected with Borna disease virus. Arch Virol 55: 209–223PubMedCrossRefGoogle Scholar
  57. Ludwig H, Kraft W, Kao M, Gosztonyi G, Dahme E, Krey HF (1985) Die Borna-Krankheit bei natürlich und experimentell infizierten Tieren: ihre Bedeutung für Forschung und Praxis. Tierarztl Prax 13: 421–453PubMedGoogle Scholar
  58. Ludwig H, Bode L, Gosztonyi G (1988) Borna disease: a persistent virus infection of the central nervous system. Prog Med Virol 35: 107–151PubMedGoogle Scholar
  59. Ludwig H, Furuya K, Bode L, Klein N, Dürrwald R, Lee DS (1993) Biology and neurobiology of Borna disease viruses (BDV), defined by antibodies, neutralizability and their pathogenic potential. Arch Virol Suppl 7: 111–133PubMedGoogle Scholar
  60. Lundgren A-L (1992) Feline non-suppurative meningoencephalomyelitis. A clinical and pathological study. J Comp Pathol 107: 411–425PubMedCrossRefGoogle Scholar
  61. Lundgren A-L, Ludwig H (1993) Clinically diseased cats with non-suppurative meningoencephalomyelitis have Borna disease virus-specific antibodies. Acta Vet Scand 34: 101–103PubMedGoogle Scholar
  62. Lundgren A-L, Czech G, Bode L, Ludwig H (1993) Natural Borna disease in domestic animals others than horses and sheep. J Vet Med B40: 298–303CrossRefGoogle Scholar
  63. Matthias D (1954) Der Nachweis von latent infizierten Pferden, Schafen und Rindern und deren Bedeutung als Virusreservoir bei der Borna’schen Krankheit. Arch Exp Vet Med 8: 506–511Google Scholar
  64. Menninger KA (1928) The schizophrenia syndrome as the product of infectious disease. Arch Neurol Psychiatry 20: 464–481Google Scholar
  65. Morales JH, Herzog S, Kompter C, Frese K, Rott R (1988) Axonal transport of Borna disease virus along olfactory pathways in spontaneously and experimentally infected rats. Med Microbiol Immunol 177: 51–68PubMedCrossRefGoogle Scholar
  66. Narayan O, Herzog S, Frese K, Scheefers K, Rott R (1983a) Pathogenesis of Borna disease in rats: immune-mediated viral ophthalmoencephalopathy causing blindness and behavioral abnormalities. J Infect Dis 148: 305–315PubMedCrossRefGoogle Scholar
  67. Narayan O, Herzog S, Frese K, Scheefers H, Rott R (1983b) Behavioral disease in rats caused by immunopathological responses to persistent Borna virus in the brain. Science 220: 1401–1403PubMedCrossRefGoogle Scholar
  68. Nicolau S, Galloway IA (1928) Borna disease and enzootic encephalomyelitis of sheep and cattle. Spec Rep Med Res Council 121: 7–90Google Scholar
  69. Pauli G, Gregersen J-P, Ludwig H (1984) Plaque/focus-immunoassay: a simple method for detecting antiviral or other antibodies and viral antigens in cells. J Immunol Methods 74: 337–344PubMedCrossRefGoogle Scholar
  70. Pette H, Környey S (1935) Über die Pathogenese und die Pathologie der Borna’schen Krankheit im Tierexperiment. Dtsch Z Nervenheilkd 136: 20–65CrossRefGoogle Scholar
  71. Pyper JM, Richt JA, Brown L, Rott R, Narayan O, Clements JE (1993) Genomic organization of the structural proteins of Borna disease virus revealed by a cDNA clone encoding the 38 kDa protein. Virology 195: 229–238PubMedCrossRefGoogle Scholar
  72. Richt JA, Stitz L (1992) Borna disease virus infected astrocytes function in vitro as antigen-presenting and target cells for virus-specific CD4-bearing lymphocytes. Arch Virol 124: 95–109PubMedCrossRefGoogle Scholar
  73. Richt JA, Stitz L, Wekerle H, Rott R (1989) Borna disease, a progressive meningoencephalomyelitis as a model for CD4+ T cell-mediated immunopathology in the brain. J Exp Med 170: 1045–1050PubMedCrossRefGoogle Scholar
  74. Richt JA, Stitz L, Deschl U, Frese K, Rott R (1990) Borna disease virus-induced meningoencephalomyelitis caused by a virus-specific CD4+ T cell-mediated immune reaction. J Gen Virol 71: 2565–2573PubMedCrossRefGoogle Scholar
  75. Richt JA, Vande Woude S, Zink MC, Narayan O, Clements JE (1991) Analysis of Borna disease virus-specific RNAs in infected cells and tissues. J Gen Virol 72: 2252–2255CrossRefGoogle Scholar
  76. Rott R, Herzog S, Fleischer B, Winokur H, Amsterdam JD, Dyson W, Koprowski H (1985) Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders. Science 228: 755–756PubMedCrossRefGoogle Scholar
  77. Rott R, Herzog S, Bechter K, Frese K (1991) Borna disease, a possible hazard for man? Arch Virol 118: 143–149PubMedCrossRefGoogle Scholar
  78. Seifried O, Spatz H (1930) Die Ausbreitung der encephalitischen Reaktion bei der Borna’sche Krankheit der Pferde und deren Beziehungen zu der Encephalitis epidemica, der Heine-Medinschen Krankheit und der Lyssa des Menschen. Eine vergleichend-pathologische Studie. Zentralbl Neurol Psychiatry 124: 317–382CrossRefGoogle Scholar
  79. Shankar V, Kao M, Hamir AN, Sheng H, Koprowski H, Dietzschold B (1992) Kinetics of virus spread and changes in levels of several cytokine mRNAs in the brain after intranasal infection of rats with Borna disease virus. J Virol 66: 992–998PubMedGoogle Scholar
  80. Sierra-Honigmann AM, Rubin SA, Estafanous MG, Yolken RH, Carbone KM (1993) Borna disease virus in peripheral blood mononuclear and bone marrow cells of neonatally and chronically infected rats. J Neuroimmunol 45: 31–36PubMedCrossRefGoogle Scholar
  81. Sprankel H, Richarz K, Ludwig H, Rott R (1978) Behavioral alterations in tree shrews (Tupaia glis, Diard 1820) induced by Borna disease virus. Med Microbiol Immunol 165: 1–18PubMedCrossRefGoogle Scholar
  82. Steinbach F, Thiele B Bode L, Zimmermann W, Ludwig H (1993) Borna disease virus is carried in monocytic cells during infection of animals (submitted)Google Scholar
  83. Steinbach F, Thiele B, (1993) Phenotypical investigation of mononuclear phagocytes by flow cytometry. J Immunol Methods 174: 109–122.CrossRefGoogle Scholar
  84. Stitz L, Krey HF, Ludwig H (1980) Borna disease in rhesus monkeys as a model for uveo-cerebral symptoms. J Med Virol 6: 333–340CrossRefGoogle Scholar
  85. Stitz L, Soeder D, Deschl U, Frese K, Rott R (1989) Inhibition of immune-mediated meningoencephalitis in persistently Borna disease virus infected rats by cyclosporine A. J Immunol 143: 4250–4256PubMedGoogle Scholar
  86. Stitz L, Schilken D, Frese K (1991) Atypical dissemination of the highly neurotropic Borna disease virus during persistent infection in cyclosporin A-treated, immunosuppressed rats. J Virol 65: 457–460PubMedGoogle Scholar
  87. Vande Woude S, Richt JA, Zink MC, Rott R, Narayan O, Clements JE (1990) A Borna virus cDNA encoding a protein recognized by antibodies in humans with behavioral diseases. Science 250:1278–1281CrossRefGoogle Scholar
  88. Zwick W (1939) Bornasche Krankheit und Encephalomyelitis der Tiere. In: Gildemeister F, Hagen E, Waldmann O (eds) Handbuch der Viruskrankheiten, vol 2. Fischer, Jena, pp 254–354Google Scholar
  89. Zwick W, Seifried O, Witte J (1927) Experimentelle Untersuchungen über die seuchenhafte GehirnRückenmarkentzündung der Pferde (Borna’sche Krankheit). Z Inf Krkh Haustiere 30: 42–136Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • L. Bode
    • 1
  1. 1.Department of VirologyRobert Koch-Institut, BundesgesundheitsamtBerlinGermany

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