Behavioral Disturbances and Pharmacology of Borna Disease
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Whether Borna disease virus (BDV) or related infectious agents cause human disease remains controversial (see Bode and Amsterdam, this volume). Nonetheless, the Borna disease (BD) system has unique features that indicate it will be of utility in elucidating the pathogenesis of human neuropsychiatric diseases. Animals infected with BDV have characteristic abnormalities in social and motor behaviors. The biologic basis for these behavioral disturbances has begun to emerge through studies in rats experimentally infected with BDV. This chapter will have three objectives: (1) describe the spectrum of behavioral disturbances in natural and experimental BD in several host species; (2) define the neuroanatomy, neuropharmacology and neurochemistry of BD in the rat system (3) draw parallels between BDV-induced behavioral syndromes and human diseases.
KeywordsNucleus Accumbens Ventral Tegmental Area Behavioral Disturbance Tree Shrew Behavioral Syndrome
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