Abstract
Originally described in the early nineteenth century as a fatal encephalitis in horses, Borna disease (BD) has become an extraordinarily valuable model for the study of both molecular mechanisms and biological consequences of persistent virus infection in the CNS (Nicolau and Galloway 1928; Zwick 1939, this volume). BD is an immune-mediated neurologic syndrome characterized by behavioral abnormalities, meningeal and parenchymal inflammatory cell infiltrates in the brain, and the accumulation of disease-specific antigen in limbic system neurons (Joest and Degen 1911; Seifried and Spatz 1930; Ludwig et al. 1988; Richt et al. 1992). As a natural infection, BD has only been confirmed to occur in horses and sheep, but experimentally it can be transmitted to an extraordinary wide range of host species, including birds, rodents and nonhuman primates (Zwick et al. 1926; Nicolau and Galloway 1928; Zwick 1939; Matthias 1954; Nitzschke 1963; Heinig 1969; Anzil et al. 1973; Ludwig et al. 1973; Metzler et al. 1976; Ludwig and Thein 1977; Sprankel et al. 1978; Stitz et al. 1980; Hirano et al. 1983, Narayan et al. 1983; Gosztonyi and Ludwig 1984; Kao et al. 1984; Ludwig et al. 1985; Waelchli et al. 1985; Richt et al. 1992). Serological data indicate that the host range may even extend to humans, although no infectious material has been isolated from human subjects (Amsterdam et al. 1985; Rott et al. 1985, 1991 ; Bode et al. 1988, 1992).
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Keywords
- Negative Polarity
- Northern Hybridization
- Tissue Culture Cell
- Persistent Virus Infection
- Infected MDCK Cell
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References
Amsterdam JD, Winokur A, Dyson W, Herzog S, Gonzalez F, Rott R, Koprowski H (1985) Borna disease virus. A possible etiologic factor in human affective disorders? Arch Gen Psychiat 42: 1093–1096
Anzil AP, Blinzinger K, Mayr A (1973) Persistent Borna virus infection in adult hamsters. Arch Gesamte Virusforsch 40: 52–57
Bause-Niedrig I, Pauli G, Ludwig H (1991) Borna disease virus-specific antigens: two different proteins identified by monoclonal antibodies. Vet Immunol Immunopathol 27: 293–301
Bause-Niedrig I, Jackson M, Schein E, Ludwig H, Pauli G (1992) Borna disease virus-specific antigens. II. The solube antigen is a protein complex. Vet Immunol Immunopathol 31: 361–369
Bode L, Riegel S, Ludwig H, Amsterdam JD, Lange W, Koprowski H (1988) Borna disease virus- specific antibodies in patients with HIV infection and with mental disorders. Lancet ii: 689
Bode L, Riegel S, Lange W, Ludwig H (1992) Human infections with Borna disease virus: seroprevalence in patients with chronic diseases and healthy individuals. J Med Virol 36: 309–315
Briese T, de la Torre JC, Lewis A, Ludwig H, Lipkin Wl (1992) Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells. Proc. Natl. Acad. Sci. USA 89:11486–11489
Briese T, Schneemann A, Lewis AJ, Park YS, Kim S, Ludwig H, Lipkin Wl (1994) Genomic organization of Borna disease virus. Proc Natl Acad Sci USA 91: 4362–4366
Carbone KM, Duchala CS, Griffin JW, Kincaid AL, Narayan O (1987) Pathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and the determinant for disease incubation. J. Virol. 61: 3431–3440
Carbone KM, Moench TR, Lipkin Wl (1991) Borna disease virus replicates in astrocytes, schwann cells and ependymal cells in persistently infected rats: location of viral genomic and messenger RNAs by in situ hybridization. J. Neuropathol. Exp. Neurol. 50: 205–214
Cubitt B, Oldstone C, de la Torre JC (1994) Sequence and genome organization of Borna disease virus. J Virol 68: 1382–1396
Cubitt B, Oldstone C, Valcarel V, de la Torre JC (1994) RNA splicing contributes to the generation of mature mRNAs of Borna disease virus, a non-segmented negative strand RNA virus. Virus Res 34: 69–79
Cubitt B, de la Torre JC (1994) Borna disease virus (BDV), a nonsegmented RNA virus, replicates in nuclei of infected cells where infectious BDV ribonucleoproteins are present. J Virol 68: 1371–1381
Compans RW, Meisen LR, de la Torre JC (1994) Virus-like particles in MDCK cells persistently infected with Borna disease virus. Virus Res 33: 261–268
Danner K (1977) Borna disease: patterns of infection. In: ter Meulen V, Katz M (eds) Slow virus infections of the central nervous system. Springer, Berlin Heidelberg New York, pp 84–88
Danner K, Mayr A (1979) In vitro studies on borna virus. II. Properties of the virus. Arch. Virol. 61: 261–271
Danner K, Lüthgen K, Herlyn M, Mayr A (1978) Vergleichende Untersuchungen über Nachweis und Bildung von Serumantikörpern gegen das Borna-Virus (in German). Zentralbl Vet Med [B] 25: 345–355
de la Torre JC, Carbone KM, Lipkin Wl (1990) Molecular characterization of the borna disease agent. Virology 179: 853–856
Dittrich W, Bode L, Ludwig H, Kao M, Schneider K (1989) Learning deficiencies in Borna disease virus- infected but clinically healthy rats. Biol Psychiatry 26: 818–828
Duchala CS, Carbone KM, Narayan O (1989) Preliminary studies on the biology of Borna disease virus. J Gen Virol 70: 3507–3511
Elford WJ, Galloway IA (1933) Filtration of the virus of Borna disease through graded collodion membranes. Br J Exp Pathol 14: 196–205
Gilden DH, Lipton HL (eds) (1989). Clinical and molecular aspects of neurotropic virus infection. Kluwer Academic, Boston
Gosztonyi G, Ludwig H (1984) Borna disease of horses. An immunohistological and virological study of naturally infected animals. Acta Neuropathol (Berl) 64: 213–221
Haas B, Becht H, Rott R (1986) Purification and properties of an intranuclear virus-specific antigen from tissue infected with borna disease virus. J Gen Virol 67: 235–241
Heinig A (1969) Die Bornasche Krankheit der Pferde und Schafe (in German). In: Röhrer H (ed) Handbuch der Virusinfektionen bei Tieren, Vol 4. Fischer, Jena, pp 83–148.
Herz C, Stavnezer E, Krug R, Gurney T (1981) Influenza virus, an RNA virus, synthesizes its messenger RNA in the nucleus of infected cells. Cell 26: 391–400
Hirano N, Kao M, Ludwig H (1983) Persistent, tolerant or subacute infection in Borna disease virus- infected rats. J Gen Virol 64: 1521–1530
Jackson DA, Caton AJ, McCready SJ, Cook PR (1982) Influenza virus RNA is synthesized at fixed sites in the nucleus. Nature 296: 366–368
Joest E, Degen K (1911) Untersuchungen über die pathologische Histologie, Pathogenese und postmortale Diagnose der seuchenhaften Gehirn-Rückenmarksentzündung (Bornasche Krankheit) des Pferdes (in German). Z Inf Krkh Haustiere 9: 1–98
Kao M, Ludwig H, Gosztonyi G (1984) Adapation of borna disease virus to the mouse. J Gen Virol 65: 1845–1849
Kliche S, Briese T, Henschen AH, Stitz L, Lipkin Wl (1994) Characterization of a Borna disease virus glycoprotein, gp18. J Virol 68: 6918–6923
Krey H, Ludwig H, Rott R (1979) Spread of infectious virus along the optic nerve into the retina in Borna disease virus-infected rabbits. Arch Virol 61: 283–288
Lipkin Wl, Travis GH, Carbone KM, Wilson MC (1990) Isolation and characterization of Borna disease agent cDNA clones. Proc Natl Acad Sci USA 87: 4184–4188
Ludwig H, Becht H (1977) Borna, the disease-a summary of our present knowledge. In: ter Meulen V, Katz M (eds) Slow virus infections of the central nervous system. Springer, Berlin Heidelberg New York, pp 75–83
Ludwig H, Thein P (1977) Demonstration of specific antibodies in the central nervous system of horses naturally infected with Borna disease virus. Med Microbiol Immunol 163: 215–226
Ludwig H, Becht H, Groh L (1973) Borna disease (BD), a slow virus infection. Biological properties of the virus. Med Microbiol Immunol 158: 275–289
Ludwig H, Koester V, Pauli G, Rott R (1977) The cerebrospinal fluid of rabbits infected with borna disease virus. Arch Virol 55: 209–223
Ludwig H, Kraft W, Kao M, Gosztonyi G, Dahme E, Krey H (1985) Borna-Virus-lnfektion (Borna-Krankheit) bei natürlich und experimentell infizierten Tieren: ihre Bedeutung für Forschung und Praxis (in German). Tierarztl Prax 13: 421–453
Ludwig H, Bode L, Gosztonyi G (1988) Borna disease: a persistent virus infection of the central nervous system. Prog Med Virol 35: 107–151
Matthias D (1954) Der Nachweis von latent infizierten Pferden, Schafen und Rindern und deren Bedeutung als Virusreservoir bei der Bornaschen Krankheit (in German). Arch Exp Vet Med 8: 506–511
McClure MA, Thibault KJ, Hatalski CG, Lipkin Wl (1992) Sequence similarity between Borna disease virus p40 and a duplicated domain within the paramyxovirus and rhabdovirus polymerase proteins. J Virol 66: 6572–6577
Metzler A, Frei U, Danner K (1976) Virologisch gesicherter Ausbruch der Bornashen Krankheit in einer Schafherde der Schweiz (in German). Schweiz Arch Tierheilkd 118: 483–492
Morales JA, Herzog S, Kompter C, Frese K, Rott R (1988) Axonal transport of Borna disease virus along olfactory pathways in spontaneously and experimentally infected rats. Med Microbiol Immunol 177: 51–68
Narayan O, Herzog S, Frese K, Scheefers H, Rott R (1983) Pathogenesis of Borna disease in rats: immune-mediated viral ophthalmoencephalopathy causing blindness and behavioral abnormalities. J Infect Dis 148: 305–315
Nicolau S, Galloway IA (1928) Borna disease and enzootic encephalo-myelitis of sheep and cattle. Stationary Office, London (Privy Council, Medical Research Council, special report series no 121)
Nitzschke E (1963) Untersuchungen über die experimentelle Bornavirus-lnfektion bei der Ratte (in German). Zentralbl Vet Med [B] 10: 470–527
Pauli G, Ludwig H (1985) Increase of virus yields and releases of Borna disease virus from persistently infected cells. Virus Res. 2: 29–33.
Pauli G, Grunmach J, Ludwig H (1984) Focus-immunoassay for borna disease virus-specific antigens. Zentralbl Vet Med [B] 31: 552–557
Richt JA, VandeWoude S, Zink MC, Narayan O, Clements JE (1991) Analysis of Borna disease virus- specific RNAs in infected cells and tissues. J Gen Virol 72: 2251–2255
Richt JA, VandeWoude S, Zink MC, Clements JE, Herzog S, Stitz L, Rott R, Narayan O (1992) Infection with Borna disease virus: molecular and immunobiological characterization of the agent. Clin. Infect Dis 14: 1240–1250
Rott R, Herzog S, Fleischer B, Winokur A, Amsterdam J, Dyson W, Koprowski H (1985) Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders. Science 228: 755–756
Rott R, Herzog S, Bechter K, Frese K (1991) Borna disease, a possible hazard for man? Arch Virol 118: 143–149
Schädler R, Diringer H, Ludwig H (1985) Isolation and characterization of a 14500 molecular weight protein from brains and tissue cultures persistently infected with Borna disease virus. J Gen Virol 66: 2479–2484
Schneeman A, Schneider PA, Kim S, Lipkin Wl (1994) Identification od signal sequences that cintrol transcription of Borna disease virus, a nonsegmented, negative-strand RNA virus. J Virol 68: 6514–6522
Schneider S, Breise T, Henschen AH, Stitz L, Lipkin Wl (1994) Characterization of a Borna disease virus glycoprotein, gp18. J Virol 68: 6918–6923
Seifried O, Spatz H (1930) Die Ausbreitung der encephalitischen Reaktion bei der Bornaschen Krankheit der Pferde und deren Beziehungen zu der Encephalitis epidemica, der Heine-Medinschen Krankheit und der Lyssa des Menschen. Eine vergleichend-pathologische Studie (in German). Z Gesamte Neurol Psychiatry 124: 317–382
Sprankel H, Richarz K, Ludwig H, Rott R (1978) Behavior alterations in tree shrews (Tupaia glis, Diard 1820) induced by Borna diseasae virus. Med Microbiol Immunol 165: 1–18
Stitz L, Krey H, Ludwig H (1980) Borna disease in Rhesus monkeys as a model for uveo-cerebral symptoms. J Med Virol 6: 333–340
ter Meulen V (ed) (1991) Virus-cell interactions in the nervous system. Seminars in neuroscience, Vol 3. London, Saunders, pp 81–123
Thiedemann N, Presek P, Rott R, Stitz L (1992) Antigenic relationship and further characterization of two major Borna disease virus-specific proteins. J Gen Virol 73: 1057–1064
Thierer J, Riehle H, Grebenstein O, Binz T, Herzog S, Thiedemann N, Stitz L, Rott R, Lottspeich F, Niemann H (1992) The 24K protein of Borna disease virus. J Gen Virol 73: 413–416.
VandeWoude S, Richt JA, Zink MC, Rott R, Narayan O, Clements JE (1990) A Borna virus cDNA encoding a protein recognized by antibodies in humans with behavioral diseases. Science 250: 1278–1281
von Sprockhoff H (1956) Zur biologischen Charakterisierung des Borna-s-Antigens (in German). Z. Immun Forsch (Jena) 113: 379–385
von Sprockhoff H, Nitzschke E (1955) Untersuchungen über das komplementbindende Antigen in Gehirnen bornavirus-infizierter Kaninchen. 1. Mitteilung: Nachweis eines löslichen Antigens (in German). Zentralbl Vet Med 2: 185–192
Waelchli RO, Ehrensperger F, Metzler A, Winder C (1985) Borna disease in a sheep. Vet Rec 117: 499–500
Wagner K, Ludwig H, Paulsen J (1968) Fluoreszenzserologischer Nachweis von Borna-Virus Antigen (in German). Berl Munch Tierarztl Wochenschr 81: 395–396
Zimmermann W, Breter H, Rudolph M, Ludwig H (1994) Borna disease virus: immunoelectron microscopic characterization of cell-free virus and further information about the genome. J Virol 68: 6755–6758
Zwick W (1939) Bornasche Krankheit und Enzephalomyelitis der Tiere (in German). In: Gildemeister E, Haagen E, Waldmann O (eds) Handbuch der Viruskrankheiten, vol 2. Fischer, Jena, pp 254–354
Zwick W, Seifried O, Witte J (1926) Experimentelle Untersuchungen über die seuchenhafte Gehirn-und Rückenmarksentzündung der Pferde (Bornasche Krankheit) (in German). Z Inf Krankh Haustiere 30: 42–136
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Briese, T., Lipkin, W.I., de la Torre, J.C. (1995). Molecular Biology of Borna Disease Virus. In: Koprowski, H., Lipkin, W.I. (eds) Borna Disease. Current Topics in Microbiology and Immunology, vol 190. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78618-1_1
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