Abstract
The network concept of the immune system as proposed by Jerne in the early 1970s [1] has gained widespread acceptance. In this concept, the idiotypes of an antibody, defined as the collection of antigenic determinants in the variable region of an antibody molecule, play a major role in the immune response. The antibodies elicited by the variable region (anti-idiotypic antibodies, anti-Id) can be divided into four major types: (a) the anti-Id (Ab2) binds to an epitope remote from the binding site (paratope) of the idiotype antibody (Abl); (b) Ab2 binds near the paratope of Abl and interferes with antigen binding; (c) Ab2 mimics the structure of the antigen recognized by Abl (so-called internal-image antibodies); (d) Ab2 recognizes a structure on a constant domain of immunoglobulin (Ig). The potential usefulness of internal-image antibodies to modulate responses to, for example, human tumor-associated antigens (TAA) have stimulated considerable interest in the development and characterization of anti-Id antibodies to these antigenic systems.
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Uemura, H., Debruyne, F.M.J., Okajima, E., Schalken, J.A., Oosterwijk, E. (1994). Tools for Vaccination and Immunotherapy: Internal-Image Anti-idiotype Antibodies Resembling the Renal Cell Carcinoma Associated Antigen G250. In: Staehler, G., Pomer, S. (eds) Contemporary Research on Renal Cell Carcinoma. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78609-9_17
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DOI: https://doi.org/10.1007/978-3-642-78609-9_17
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