Historical Remarks on Metastasis and Metastatic Bone Disease

  • I. J. Diel
Conference paper


When one looks back over the history of man’s efforts to understand and treat metastasis and metastatic bone disease, the principal feature from today’s perspective is the radical evolution in the basic concept of metastasis. And because the concept has evolved with developments and discoveries outside the specific area of oncology, historical theories about metastasis must be seen in the context of advances in medical science in general: from humoral to solidistic and finally to cell pathology. This chapter therefore discusses, first, the history of basic oncological concepts, and then considers metastatic bone disease.


Lymph Vessel Secondary Growth Metastatic Bone Disease Humoral Theory Historical Remark 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1994

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  • I. J. Diel

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