Mutation: Higher Plants

  • Werner Gottschalk
Part of the Progress in Botany/Fortschritte der Botanik book series (BOTANY, volume 55)


The intensive studies on the mutagenicity of some luxuries have been continued during the past years. This is particularly valid with regard to tobacco. To discern the effects of cigarette smoke condensates or extracts, different human cells of smokers, especially lymphocytes, were evaluated, but also mice cells and rat urine. The frequency of micro– nuclei and of sister chromatid exchanges (SCEs) in the cells was used as parameter. Moreover, the mutagenicity of tobacco extracts on Salmonella typhimurium was studied. The following findings were obtained:

  • A significant increase in the frequency of SCEs and in micronuclei in the cells of smokers was found by Jørgensen et al. (1991) and by Larramendy and Knuutila (1991).

  • Cigarette smoke condensate was found to induce partial mitotic arrest in human lymphoid cell lines, increasing the frequency of metaphases and decreasing the proportion of anaphases. These effects are possibly due to the presence of antimitotic compounds in the condensate (Hsu et al. 1991).

  • The mutagenicity of polyaromatic amines was enhanced through cigarette smoke condensates in Salmonella (Crebelli et al. 1991).

  • The urinary mutagenicity of cigarette smoke condensates was increased in rats after injection. After inhalation of cigarette smoke, however, this effect was not observed (Doolittle et al. 1991).


International Atomic Energy Agency Somatic Hybrid Chromosome Aberration Somaclonal Variation Mesophyll Protoplast 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Werner Gottschalk
    • 1
  1. 1.Institut für Genetikder Universität BonnBonnGermany

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