Toxoplasma Gondii: Chemotherapy
Infection with Toxoplasma gondii is widespread and has been observed in man and in almost all warm-blooded animals. Most immunologically normal adults acutely infected with T. gondii present only self-limited symptoms and signs. This is in great contrast with the morbidity and mortality that is observed in children with congenital and acquired toxoplasmosis, and in immunocompromised patients, notably those affected by the acquired immune deficiency syndrome (AIDS). Prompt antimicrobial therapy is given to patients with the aim of inhibiting the replication of the parasite and to prevent or to reduce the tissue damage resulting from parasitic intracellular multiplication. This therapy, nevertheless, is inactive against the non-multiplying (extracellular) or metabolically inactive (cyst) form of the parasite. Therapy of toxoplasmosis is further complicated by the possibility of harmful effects of the drugs on the fetus during therapy of pregnant women infected for the first time with T. gondii. The high frequency of side effects observed in AIDS patients treated for toxoplasmic encephalitis may lead to withdrawal of therapy and this enhances the possibilities of recurrent disease. All these considerations, therefore, point out the need for safer alternatives in the therapy of toxoplasmosis.
KeywordsMalaria Adenine Pyrimidine Nucleoside Guanine
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