Toxoplasmosis pp 163-168 | Cite as

Human T-Cell Clones as Tools to Identify Protective Antigens of Toxoplasma Gondii

  • P. Hérion
  • R Saavedra
Conference paper
Part of the NATO ASI Series book series (volume 78)

Abstract

Many in vitro and in vivo observations indicate that cell-mediated immunity plays an essential role in protection of the host against toxoplasmosis. In the mouse experimental model, it has recently been shown that both CD4+ and CD8+ lymphocytes are important in controlling acute infection and preventing reactivation of chronic toxoplasmosis [Suzuki and Remington, 1988; Araujo, 1991; Gassinelli et al, 1991; Gazzinelli et al 1992]. The exact mechanism by which these T-cell subsets confer protection has not yet been fully elucidated, but two lymphokines (IL-2 and IFN-γ) produced by these T-cells have been demonstrated to have a protective activity [Sharma et al., 1985]; Suzuki et al., 1988; Suzuki and Remington, 1990; Suzuki et al. 1990; Gazzinelli et al., 1991]. Parasite-specific T-cell clones (TCC) derived from naturally infected and immune individuals offer an ingenious way to dissect the cell-mediated immune response and to identify the parasite antigens which induce protective effector mechanisms. Such antigens should thus be considered as subunit vaccine candidates.

Keywords

Polypeptide Interferon Encephalitis Toxoplasmosis 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • P. Hérion
    • 1
  • R Saavedra
    • 2
  1. 1.Innogenetics N.V.GhentBelgium
  2. 2.Departamento de Immunologia, Instituto de Investigaciones BiomédicasUniversidad Nacional Autonoma de Mexico, AP 70228, Ciudad UniversitariaMexico DFMexico

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