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Toxoplasma Gondii: Patterns of Bradyzoite-Tachyzoite Interconversion In Vitro

  • Martine Soete
  • Bernard Fortier
  • Daniel Camus
  • Jean Francois Dubremetz
Part of the NATO ASI Series book series (volume 78)

Abstract

The development of Toxoplasma gondii in the intermediate host is believed to be a balance between the parasite and the immune system of the host which leads to either of the two possible developmental stages that are tachyzoites or bradyzoites. Alteration of the balance leads to interconversion between these stages [Frenkel et al, 1975]. The relations between the immune response and the mechanism(s) of interconversion are unknown. Since analyzing these phenomena in the host is complex, we have started investigating this phenomenon in vitro. We have confirmed the previous description by others of strains producing both stages in vitro in the absence of any immunological effector [Hoff et al, 1977; Darde et al, 1989]. This system will be used to characterize the essential requirements for differentiation toward either of the two stages. The strategy developed towards this goal is as follows: first to obtain stages specific probes; second to follow spontaneous differentiation in vitro, and third to find ways of manipulating differentiation in order to define the mechanisms involved. The first two steps will be described in this report.

Keywords

Dense Granule Toxoplasma Gondii Parasitophorous Vacuole Congenital Toxoplasmosis Spontaneous Differentiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Martine Soete
    • 1
  • Bernard Fortier
    • 1
  • Daniel Camus
    • 1
  • Jean Francois Dubremetz
    • 1
  1. 1.INSERM Unite 42Villeneuve d’AscqFrance

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