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Regulation of HIV Replication in Monocytes by Interferon

  • J. A. Turpin
  • S. X. Fan
  • B. D. Hansen
  • M. L. Francis
  • L. M. Baca-Regen
  • H. E. Gendelman
  • M. S. Meltzer
Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 14)

Abstract

The hallmark of human immunodeficiency virus (HIV) infection is the progressive loss of CD4+ T-cells over a prolonged interval. In the infected individual, two types of cells are infected by HIV: CD4+ T-cells and tissue macrophages. Levels of HIV in blood and tissues are dependent upon and change with the stage of the infection. Acute infection, usually lasting weeks to months after initial exposure to the virus, is characterized by a substantial viremia in which HIV actively replicates within blood leukocytes and high titers of free virus are found in plasma (more than 10 000 infectious virions/ml blood) (Clark et al. 1991; Daar et al. 1991). The chronic subclinical phase of infection is notable for low levels of plasma viremia and of virus-infected cells (less than 100 infectious virions/ml blood) (Ho et al. 1989). The major reservoirs for HIV in blood are CD4+ T-cells which are infected at a frequency of about 0.1 to 1% (Schnittman et al. 1989). HIV-infected CD4+ T-cells have on average only one proviral DNA copy integrated into genomic DNA. Less than 0.1% of these infected cells is transcriptionally active at any given time (Harper et al. 1986; Simmonds et al. 1990). During subclinical infection, the frequency of blood cells that express HIV mRNA and presumably produce infectious virus is only 0.01% (Harper et al. 1986; Clarke et al. 1990; Daar et al. 1991). During subclinical disease when very few cells are producing virus in blood, it is likely that cells in tissue provide most of the actively replicating virus that maintains infection during the long latent interval of 8 to 12 years (Lifson et al. 1988).

Keywords

Human Immunodeficiency Virus Human Immunodeficiency Virus Type Human Immunodeficiency Virus Infection Long Terminal Repeat Human Immunodeficiency Virus Replication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aboud M, Hassan Y (1983) Accumulation and breakdown of RNA-deficient intracellular viron particles in interferon-treated NIH 3T3 cells chronically producing Moloney murine leukemia virus. J Virol 45:489–495.PubMedGoogle Scholar
  2. Baca LM, Genis P, Zhou A, Silverman RH, Lamer A, Meltzer MS, Gendelman HE (1992) Regulation and antiviral activities of interferon α inducible genes in human immunodeficiency virus infected monocytes. J Exp Med (submitted).Google Scholar
  3. Baldwin AS, LeClai KP, Harinder S, Sharp PA (1990) A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompata-bility complex and kappa immunoglobulin genes. Mol Cell Biol 10:1406–1414.PubMedGoogle Scholar
  4. Bandyopadhyay AK, Chang EH, Levi CC, Friedman RM (1979) Structural abnormalities in murine leukemia viruses produced by interferon treated cells. Biochem Biophys Res Commun 87:983–988.PubMedGoogle Scholar
  5. Bell DM, Roberts NJ Jr, Hall CB (1983) Different antiviral spectra of human macrophage interferon activities. Nature 305:319–321.PubMedGoogle Scholar
  6. Berkhout B, Gatignol A, Rabson AB, Jeang K-T (1990) TAR-independent activation of the HIV-1 LTR: evidence that TAT requires specific regions of the promoter. Cell 62:757–767.PubMedGoogle Scholar
  7. Brinchmann JE, Gandernack G, Vartdal F (1991) In vitro replication of HIV-1 in naturally infected CD4+ T cells is inhibited by rIFN-α2 and by a soluble factor secreted by activated CD8+ T cells but not by rIFN-β rIFN-γ or TNF-α. J AIDS 4:480–488.Google Scholar
  8. Cameron PU, Dawkins RL, Armstrong JA, Bonifacio E (1987) Western blot profiles, lymph node ultra-structure and viral expression in HIV-infected patients: a correlative study. Clin Exp Immunol 68:465–478.PubMedGoogle Scholar
  9. Capobianchi MR, Ankel H, Ameglio F, Paganelli R, Pizzoli PM, Dianzani F (1992) Recombinant glycoprotein 120 of human immunodeficiency virus is a potent interferon inducer. AIDS Res Hum Retroviruses 8:575–579.PubMedGoogle Scholar
  10. Carter WA, Brodsky I, Pellegrino MG, Henriques HF et al. (1987) Clinical, immunological, and virological effects of ampligen, a mismatched double-stranded RNA, in patients with AIDS or AIDS-related complex. Lancet i: 1286–1292.Google Scholar
  11. Cauda R, Tyring SK, Tamburrini E, Ventura G, Tambarello M, Ortona L (1987/1988) Diminished interferon gamma production may be the earliest indicator of infection with the human immunodeficiency virus. Viral Immunol 1:247–258.PubMedGoogle Scholar
  12. Chang EH, Friedman RM (1977) A large glycoprotein of Moloney murine leukemia virus derived from interferon treated cells. Biochem Biophys Res Commun 77:392–397.PubMedGoogle Scholar
  13. Chang EH, Mayers MW, Wong KY, Friedman RM (1977) The inhibitory effect of interferon on a temperature-sensitive mutant of moloney murine leukemia virus. Virology 77:625–636.PubMedGoogle Scholar
  14. Clark SJ, Saag MS, Don Decker W et al. (1991) High titers of cytopathic virus in plasma of patients with symptomatic primary HIV infection. New Eng J Med 324:954–960.PubMedGoogle Scholar
  15. Clarke JR, Krishnan V, Bennett J, Mitchell D, Jeffries DJ (1990) Detection of HIV in human lung macrophages using the polymerase chain reaction. AIDS 4:1133–1136.PubMedGoogle Scholar
  16. Cullen BR (1991) Regulation of gene expression in the human immunodeficiency virus type 1. Adv Virus Res 40:1–17.PubMedGoogle Scholar
  17. Daar ES, Moudgil T, Meyer RD, Ho DD (1991) Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. New Engl J Med 324:961–964.PubMedGoogle Scholar
  18. Dedera DN, Vander Hayden N, Ratner L (1990) Attenuation of HIV-1 infectivity by an inhibitor of oligosaccharide processing. AIDS Res Hum Retroviruses 6:785–794.PubMedGoogle Scholar
  19. Destefano A, Firedman R, Friedman-Kien A, Goedert JJ et al. (1982) Acid-labile human leukocyte interferon in homosexual men with Kaposi’s sarcoma and lymphadenopathy. J Infect Dis 146:451–459.PubMedGoogle Scholar
  20. Dolei A, Fattorossi A, D’Amelio R, Aiuti F, Dainzani F (1986) Direct and cell-mediated effects of interferon-α and γ on cells chronically infected with HTLV-III. J Interferon Res 6:543–549.PubMedGoogle Scholar
  21. Edery I, Petryshyn R, Sonenberg N (1989) Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-2 mRNA: a novel translational control mechanism. Cell 56:303–312.PubMedGoogle Scholar
  22. Enk C, Gerstoft J, Molles S, Remvig L (1986) Interleukin 1 activity in the acquired immunodeficiency syndrome. Scand J Immunol 23:491–497.PubMedGoogle Scholar
  23. Farrar WL, Korner M, Clouse KA (1991) Cytokine regulation of human immunodeficiency virus expression. Cytokine 3:531–542.PubMedGoogle Scholar
  24. Felber BK, Hadzopoulou-Cladaras M, Cladaras C, Copeland T, Pavlakis GN (1989) Rev protein of human immunodeficiency virus type 1 affects stability and transport of the viral mRNA. Proc Natl Acad Sci USA 86:1495–1499.PubMedGoogle Scholar
  25. Felber BK, Drysdale CM, Pavlakis GN (1990) Feedback regulation of human immunodeficiency virus type 1 expression by the rev protein. J Virol 64:3734–3741.PubMedGoogle Scholar
  26. Finbloom DS, Hoover DL, Meltzer MS (1991) Binding of recombinant HIV coat gp 120 to human monocytes. J Immunol 146:1316–1321.PubMedGoogle Scholar
  27. Geleziunas R, Bour S, Boulerice F, Hiscott J, Wainberg MA (1990) Diminution of CD4 surface protein but not CD4 messenger RNA levels in monocytic cells infected by HIV-1. AIDS 5:29–33.Google Scholar
  28. Gendelman HE, Orenstein JM, Martin MA, Ferrua C et al. (1988) Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes. J Exp Med 167:1428–1441.PubMedGoogle Scholar
  29. Gendelman HE, Baca L, Husayni H et al. (1990a) Macrophage-human immunodeficiency virus interaction: viral isolation and target cell tropism. AIDS 4:221–228.PubMedGoogle Scholar
  30. Gendelman HE, Baca L, Turpin JA, Kalter DC, Hansen BD, Orenstein JM, Diffenbach CW, Friedman RM, Meltzer MS (1990b) Regulation of HIV replication in infected monocytes by IFN-α: mechanisms for viral restriction. J Immunol 145:2669–2676.PubMedGoogle Scholar
  31. Gendelman HE, Baca L, Turpin JA, Kalter C, Hansen BD, Orenstein JM, Friedman RM, Meltzer MS (1990c) Restriction of HIV replication in infected T cells and monocytes by interferon-α. AIDS Res Hum Retroviruses 6:1045–1049.PubMedGoogle Scholar
  32. Gendelman HE, Friedman RM, Joe S, Baca LM, Turpin JA, Dveksler G, Meltzer MS, Dieffenbach C (1990d) A selective defect of interferon a in human immunodeficiency virus-infected monocytes. J Exp Med 172:1433–1442.PubMedGoogle Scholar
  33. Gendelman HE, Baca LM, Kubrak CA, Genis P, Burrous S, Friedman RM, Munch D, Meltzer MS (1992) Induction of interferon a in peripheral blood mononuclear cells by human immunodeficiency virus (HIV)-infected monocytes: restricted antiviral activity of the HIV-induced interferons. J Immunol 148:422–429.PubMedGoogle Scholar
  34. Ghosh S, Gifford AM, Riviere LR, Tempst P, Nolan GP, Baltimore D (1990) Cloning of the p50 DNA binding subunit of NF-κ B: homology to rel and dorsal. Cell 62:1019–1029.PubMedGoogle Scholar
  35. Gomatos PJ, Stamatos NM, Gendelman HE et al. (1990) Lack of effect for recombinant soluble CD4 on infection of human monocytes by HIV. J Immunol 144:4183–4188.PubMedGoogle Scholar
  36. Goren T, Fischer DG, Rubinstein M (1986) Human monocytes and lymphocytes produce different mixtures of α-interferon subtypes. J Interferon Res 6:323–329.PubMedGoogle Scholar
  37. Griffin GE, Leung K, Folks TM, Kunkel S, Nabel GJ (1989) Activation of HIV gene expression during monocyte differentiation by induction of NF-κ B. Nature 339:70–73.PubMedGoogle Scholar
  38. Hansen BD, Nara PL, Maheshwas RK, Sidhu G, Bernbaum JG, Hoekzema D, Meltzer MS, Gendelman HE (1992) Loss of infectivity by progeny virus from interferon α-treated human immunodeficiency virus type 1-infected T cells is associated with defective assembly of envelope gpl20. J Virol 66:7543–7548.PubMedGoogle Scholar
  39. Harper ME, Marselle LM, Gallo RC, Wong-Staal F (1986) Detection of lymphocytes expressing human T-lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridization. Proc Natl Acad Sci USA 83:772–776.PubMedGoogle Scholar
  40. Hartshorn KL, Neumeyer D, Vogt MW, Schooley RT, Hirsch MS (1987) Activity of interferons alpha, beta and gamma against human immunodeficiency virus replication in vitro. AIDS Res Hum Retroviruses 3:125–133.PubMedGoogle Scholar
  41. Ho DD, Rota TR, Kaplan JC, Hartshorn KL, Andrews CA, Schooley TR, Hirsch MS (1985) Recombinant human interferon Alfa-a suppresses HTLV-III replication in vitro. Lancet 1: 602–604.PubMedGoogle Scholar
  42. Ho DD, Moudgil T, Alam M (1989) Quantitation of human immunodeficiency virus type 1 in the blood of infected persons. N Engl J Med 321:1621–1625.PubMedGoogle Scholar
  43. Hwang SS, Boyle TJ, Lyerly HK, Cullen BR (1991) Identification of envelope V3 loop as the primary determinant of cell tropism in HIV. Science 253:71–74.PubMedGoogle Scholar
  44. Jones KA, Kadonaga JT, Luciw PA, Tijan R (1986) Activation of the AIDS retrovirusus promoter by the cellular transcription factor, Spl. Science 232:755–759.PubMedGoogle Scholar
  45. Kalter DC, Nakamura M, Turpin JA et al. (1991) Enhanced HIV replication in MCSF-treated monocytes. J Immunol 146:298–306.PubMedGoogle Scholar
  46. Kieran M, Blank V, Logeat F, Vandekerckhove J, Lottspeich F, Le Bail O, Urban MB, Kourilsky P, Baeuerle PA, Israel A (1990) The DNA binding subunit of NF-κ B is identical to factor KBF-1 and homologous to the rel oncogene product. Cell 62:1007–1018.PubMedGoogle Scholar
  47. Klotman ME, Kim S, Buchbinder A, DeRossi A, Baltimore D, Wong-Staal F (1991) Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes. Proc Natl Acad Sci USA 88:5011–5015.PubMedGoogle Scholar
  48. Koenig S, Gendelman HE, Orenstein JM et al. (1986) Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 233:1089–1093.PubMedGoogle Scholar
  49. Kornbluth RS, Oh PS, Munis JR, Cleveland PH, Richman DD (1990) The role of interferons in the control of HIV replication in macrophages. Clin Immunol Immunopathol 54:200–219.PubMedGoogle Scholar
  50. Koyahagi Y, O′Brien WA, Zhao JQ, Golde DW, Gasson JC, Chen ISY (1988) Cytokines alter production of HIV-1 from primary mononuclear phagocytes. Science 241:1673–1675.Google Scholar
  51. Lahdevirta J, Maury CPJ, Teppo AM, Repo H (1988) Elevated levels of circulating cachectin/ tumor necrosis factor in patients with acquired immunodeficiency syndrome. Am J Med 85:289–291.PubMedGoogle Scholar
  52. Lau AS, Read SE, Williams BRG (1988) Downregulation of interferon α but not γ receptor in vivo in the acquired immunodeficiency syndrome. J Clin Invest 82:1415–1421.PubMedGoogle Scholar
  53. Laurence J (1990) Immunology of HIV infection, I: biology of the interferons. AIDS Res Hum Retroviruses 6:1149–1156.PubMedGoogle Scholar
  54. Lepe-Zuniga JL, Mansell PWA, Hersh EM (1987) Idiopathic production of interleukin-1 in the acquired immunodeficiency syndrome. J Clin Microbiol 25:1695–1700.PubMedGoogle Scholar
  55. Lifson AR, Rutherford GW, Jaffe HW (1988) The natural history of human immunodeficiency virus infection. J Infect Dis 158:1360–1367.PubMedGoogle Scholar
  56. Lynn WS, Tweedale A, Cloyd MW (1988) Human immunodeficiency virus (HIV-1) cytotoxicity: perturbation of the cell membrane and depression of phospholipid synthesis. Virology 163:43–51.PubMedGoogle Scholar
  57. Mace K, Gazzolo L (1991) Interferon-regulated viral replication in chronically HIV 1-infected promonocytic U937 cells. Res Virol 142:213–220.PubMedGoogle Scholar
  58. Maheshwari RK, Manerjee DK, Waechter CJ, Olden K, Friedman RM (1980) Nature 287:454–458.PubMedGoogle Scholar
  59. Malim MH, Hauber J, Fenrick R, Cullen BR (1988) Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes. Nature 335:181–183.PubMedGoogle Scholar
  60. Mann DL, Gartner S, LeSane F, Blattnere WA, Popovic M (1990) Cell-surface antigens and function of monocytes and a monocyte-like cell line before and after infection with HIV. Clin Immunol Immunopathol 54:174–183.PubMedGoogle Scholar
  61. Marciniak RA, Garcia-Blanco MA, Sharp PA (1990) Identification and charcterization of a HeLα nuclear protein that specifically binds to the trans-activating-response (tar) element of human immunodeficiency virus. Proc Natl Acad Sci USA 87:3624–3628.PubMedGoogle Scholar
  62. Matsuyama T, Kobayashi N, Yamamoto N (1991) Cytokines and HIV infection: is AIDS a tumor necrosis factor disease? AIDS 5:1405–1417.PubMedGoogle Scholar
  63. Meltzer MS, Skillman DR, Hoover DL, Hanson BD, Turpin JA, Kalter DC, Gendelman HE (1990) Macrophages and the immunodeficiency virus. Immuno Today 11:217–223.Google Scholar
  64. Meylan PR, Guatelli JC, Munis JR, Kornbluth RS, Richman DD (1991) Interferons inhibit the replication of HIV-1 in macrophages by reducing both viral DNA and regulatory gene mRNAs. Int Conf AIDS 7:60 (Abstr TU.A.20).Google Scholar
  65. Michaelis B, Levy JA (1989) HIV replication can be blocked by recombinant human interferon beta. AIDS 3:27–31.PubMedGoogle Scholar
  66. Molina J-M, Scadden DT, Amirault C, Woon A, Vannier E, Dinarello CA, Groopman JE (1990a) Human immunodeficiency virus does not induce interleukin-1, interleukin-6 or tumor necrosis factor in mononuclear cells. J Virol 64:2901–2906.PubMedGoogle Scholar
  67. Molina J-M, Schindler R, Ferriana R, Sakaguchi M, Vannier E, Dinarello CA, Groopman JE (1990b) Production of cytokines by peripheral blood monocytes/macrophages infected with human immunodeficiency virus type 1 (HIV-1). J Infect Dis 161:888–893.PubMedGoogle Scholar
  68. Muchardt C, Seeler J-S, Nirula A, Shurland D-L, Gaynor RB (1992) Regulation of human immunodeficiency virus enhancer function by PRDII-BF-1 and c-rel gene products. J Virol 66:244–250.PubMedGoogle Scholar
  69. Nathan CF, Cohen ZA (1985) Cellular components of inflammation: monocytes and macrophages. In: Kelly WN, Harris ED, Ruddy S, Sledge CB (eds) Text book of rheumatology, vol 1. Saunders, New York, p 144.Google Scholar
  70. Nelbock P, Dillon PJ, Perkins A, Rosen CA (1990) A cDNA for a protein that interacts with the human immunodeficiency virus tat transactivator. Science 248:1650–1653.PubMedGoogle Scholar
  71. Oka S, Urayama K, Hirabayashi Y, Kimura S, Mitamura K, Shimada K (1992) Human immunodeficiency virus DNA copies as a virologie marker in a clinical trial with ß-interferon. J AIDS 5:707–711.Google Scholar
  72. Olafsson K, Smith MS, Marshburn P, Carter SG, Haskill S (1991) Variation of HIV infectibility of macrophages as a function of donor, stage of differentiation, and site of origin. J AIDS 4:154–164.Google Scholar
  73. Orenstein JM, Meltzer MS, Phillips T, Gendelman HE (1988) Cytoplasmic assembly and accumulation of human immunodeficiency virus types 1 and 2 in recombinant human colony-stimulating factor-1-treated human monocytes: an ultrastructural study. J Virol 62:2578–2586.PubMedGoogle Scholar
  74. Pestka S, Langer JA, Zoon KC, Samuel CE (1987) Interferons and their actions. Annu Rev Biochem 56:727–777.PubMedGoogle Scholar
  75. Pitha PM (1991) Multiple effects of interferon on HIV-1 replication. J Interferon Res 11:313–318.PubMedGoogle Scholar
  76. Pitha PM, Fernie B, Maldarelli F, Hattman T, Wivel NA (1980) Effect of interferon on mouse leukemia virus (MuLV) V. Abnormal proteins in virons of Rauscher MuLV produced in the presence of interferon. J Gen Virol 46:97–110.PubMedGoogle Scholar
  77. Plata F, Autran B, Martins LP et al. (1987) AIDS virus-specific cytotoxic T lymphocytes in lung disorders. Nature 328:248–251.Google Scholar
  78. Poli G, Orenstein JM, Kinter A, Folks TM, Fauci AS (1989) Interferon-α but not AZT suppresses HIV expression in chronically infected cell lines. Science 244:575–577.PubMedGoogle Scholar
  79. Pomerantz RJ, Hirsch MS (1987) Interferon and human immunodeficiency virus infection. Interferon 9:114–127.Google Scholar
  80. Popik W, Pitha PM (1991) The inhibition by interferon of Herpes simplex virus type 1-activated transcription of fat defective virus. Proc Natl Acad Sci USA 88:9573–9577.PubMedGoogle Scholar
  81. Popovic M, Gartner S (1987) Isolation of HIV from monocytes but not T lymphocytes. Lancet ii:916.Google Scholar
  82. Rich EA, Chen ISY, Zack JA, Leonard ML, O’Brien WA (1992) Increased susceptibility of differentiated mononuclear phagocytes to productive infection with human immunodeficiency virus-1 (HIV). J Clin Invest 89:176–183.PubMedGoogle Scholar
  83. Robert-Guroff M, Popovic M, Gartner S, Markham P, Gallo RC, Reitz MS (1990) Structure and expression of tat-, rev-, and nef-specific transcripts of human immunodeficiency virus type 1 infected lymphocytes and monocytes. J Virol 64:3391–3398.PubMedGoogle Scholar
  84. Roberts NJ Jr, Douglas RG Jr, Simons RM, Diamond EE (1979) Virus induced interferon production by human macrophages. J Immunol 123:365–369.PubMedGoogle Scholar
  85. Ron D, Braiser AR, Haebner JF (1991) Angiotensin gene-inducible enhancer-binding protein I, a member of a new family of large nuclear proteins that recognize NF-κ B sites through a zinc finger motif. Mol Cell Biol 11:2887–2895.PubMedGoogle Scholar
  86. Rose RM, Krivine V, Pinkston P, Gillis JM, Huang A, Hammer SM (1991) Frequent identification of HIV DNA in broncoalveolar lavage cells obtained from individuals with the acquired immunodeficiency syndrome. Am Rev Respir Dis 143:850–854.PubMedGoogle Scholar
  87. Ross EK, Buckler-White AJ, Rabson AB, Englund G, Martin MA (1991) Contribution of NF-κ B and Spl binding motifs to the replicative capacity of human immunodeficiency virus type 1: distinct patterns of viral growth are determined by T-cell types. J Virol 65:4350–4358.PubMedGoogle Scholar
  88. Rossol S, Voth R, Laubenstein HP, Müller WEG, Schroder HC, Meyerzum Büschenfeld KH, Hess G (1989) Interferon production in patients infected with HIV-1. J Infect Dis 159:815–821.PubMedGoogle Scholar
  89. Roy S, Katze MG, Parkin NT, Edery I, Hovanessian AG, Sonenberg N (1990) Control of the interferon-induced 68-kilodalton protein kinase by the HIV-1 tat gene product Science 247:1216–1219.PubMedGoogle Scholar
  90. Ruben S, Dillon PF, Schreck R, Henkel T, Chen CH, Maher PA, Baeuerle PA, Rosen CA (1991) Isolation of a rel-related human cDNA that potentially encodes a 65 kD subunit of NF-κ B. Science 251:1490–1493.PubMedGoogle Scholar
  91. Saksela E, Virtanen I, Hovi T, Sécher DS, Cantell K (1984) Monocyte is the main producer of human leukocyte α-interferons following Sendai virus induction. Prog Med Virol 30:78–86.PubMedGoogle Scholar
  92. Samuel CE, Khutson GS, Masters PS (1982) Mechanism of interferon action: ability of cloned human type-alpha interferons to induce protein phosphorylation and inhibit virus replication is specified by the host cell rather than the interferon subspecies. J Interferon Res 2:97–108.Google Scholar
  93. Sato H, Orenstein J, Dimitrov D, Martim M (1992) Cell to cell spread of HIV occurs within minutes and may not involve the participation of virus particles. Virology 186:712–724.PubMedGoogle Scholar
  94. Schnizlein-Blick CT, Sherman MR, Boggs DL, Leemhuis TB, Fife KH (1992) Incidence of HIV infection in monocyte subpopulations characterized by CD4 and HLA-DR surface density. AIDS 6:151–156.Google Scholar
  95. Schnittman SM, Sallipopoulos MC, Lane HC (1989) The reservoir for HIV in human peripheral blood is a T cell that maintains expression of CD4. Science 245:305–308.PubMedGoogle Scholar
  96. Schröder HC, Wenger R, Kuchino Y, Müller WEG (1989) Modulation of nuclear matrix-associated 2,5-oligoadenylate metabolism and ribonuclease L activity in H9 cells by human immunodeficiency virus. J Biol Chem 264:5669–5673.PubMedGoogle Scholar
  97. Schröder HC, Ugarkovic D, Wenger R, Reuter P, Okamoto T, Müller WEG (1990) Binding of tat protein to TAR region of human immunodeficiency virus type-1 blocks TAR-mediated activation of (2′-5′)oligoadenylate synthetase. AIDS Res Hum Retro viruses 6:659–672.Google Scholar
  98. Schuitemaker H, Kootstra NA, de Goede REY, De Wolf F, Miedema F, Tersmette M (1991) monocytrophic human immunodeficiency virys type 1 (HIV) variants detectable in all stages of HIV infection lack T cell line tropism and syncytium-inducing ability in primary T cell culture. J Virol 65:356–363.PubMedGoogle Scholar
  99. SenGupta N, Silverman RH (1989) Activation of interferon-regulated, dsRNA-dependent enzymes by human immunodeficiency virus-1 leader RNA. Nucleic Acids Res 17:969–976.PubMedGoogle Scholar
  100. Shaw GM, Harper ME, Hahn BH et al. (1985) HTLV-III infection in brains of children and adults with encephalopathy. Science 227:177–182.PubMedGoogle Scholar
  101. Shirazi Y, Pitha PM (1992) Alpha interferon inhibits early stages of human immunodeficiency virus type 1 replication cycle. J Virol 66:1321–1328.PubMedGoogle Scholar
  102. Simmonds P, Balfe P, Peutherer JF, Ludlam CA, Bishop JO, Leigh Brown AJ (1990) Human immunodeficiency virus-infected individuals contain provirus in small numbers of peripheral mononuclear cells at low copy number. J Virol 64:864–872.PubMedGoogle Scholar
  103. Singh UK, Maheshwari RK, Damewood GP IV, Stephensen CB, Oliver C, Freidman RM (1988) Interferon alters intracellular transport of vesicular stomatitis virus glycoprotein. J Biol Reg Homeo Agents 2:53–62.Google Scholar
  104. Staeheli P (1990) Interferon-induced proteins and the antiviral state. Adv Virus Res 38:147–200.PubMedGoogle Scholar
  105. Steffy K, Wong-Staal F (1991) Genetic regulation of human immunodeficiency virus. Microbiol Rev 55:193–205.PubMedGoogle Scholar
  106. Taylor JL, Grossberg SE (1990) Recent progress in interferon research: molecular mechanisms of regulation, action and virus circumvention. Virus Res 15:1–26.PubMedGoogle Scholar
  107. Trono D, Baltimore D (1990) A human cell factor is essential for HIV-1 rev action. EMBO J 9:4155–4160.PubMedGoogle Scholar
  108. Vaishnav YN, Wong-Staal F (1991) The biochemistry of AIDS. Annu Rev Biochem 60:577–630.PubMedGoogle Scholar
  109. Vaishnav YN, Vaishnav M, Wong-Staal F (1991) Identification and characterization of a nuclear factor that specifically binds to the rev response element (RRE) of human immunodeficiency virus type 1 (HIV-1). New Bio 3:142–150.Google Scholar
  110. Valentin A, von Gegerfelt A, Matsuda S et al. (1991) In vitro maturation of mononuclear phagocytes and susceptibility to HIV-1 infection. J AIDS 4:751–759.Google Scholar
  111. Vazeux R, Brousse N, Jarry A et al. (1987) AIDS subacute encephalitis. Identification of HIV-infected cells. Am J Pathol 126:403–410.PubMedGoogle Scholar
  112. von Sydow M, Sonnerborg A, Gaines H, Stronnegard O (1991) Interferon-alpha and tumor necrosis factor-alpha in serum of patients in various stages of HIV infection. AIDS Res Hum Retro viruses 4:375–380.Google Scholar
  113. Willey RL, Bonifacino JS, Potts BJ, Martin MA, Klausner RD (1988) Biosynthesis, cleavage, and degradation of the human immunodeficiency virus type 1 envelope glycoprotein gpl60. Proc Natl Acad Sci USA 85:9580–9584.PubMedGoogle Scholar
  114. Wright SC, Jewett A, Mitsuyasu R, Bonavida B (1988) Spontaneous cytotoxicity and tumor necrosis factor production by peripheral blood monocytes from AID patients. J Immunol 141:99–104.PubMedGoogle Scholar
  115. Yagi MJ, King NW Jr, Bekesi G (1980) Alterations of mouse mammary tumor virus glycoprotein with interferon treatment. J Virol 34:225–233.PubMedGoogle Scholar
  116. Yamada O, Hattori N, Kurimura T, Kita M, Tsunataro K (1988) Inhibition of growth of HIV by human natural interferon in vitro. AIDS Res Hum Retroviruses 4:287–294.PubMedGoogle Scholar
  117. Zack JA, Arrigo SJ, Chen ISY (1990) Control of expression and cell tropism of human immunodeficiency virus type 1. Adv Virus Res 38:125–146.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • J. A. Turpin
  • S. X. Fan
  • B. D. Hansen
  • M. L. Francis
  • L. M. Baca-Regen
  • H. E. Gendelman
  • M. S. Meltzer
    • 1
  1. 1.HIV Immunopathogenesis Program, Department of Cellular ImmunologyWalter Reed Army Institute of ResearchUSA

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