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Activation of the dsRNA-Dependent Kinase

  • R. A. Petryshyn
  • J. Li
  • R. Judware
Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 14)

Abstract

The double-stranded RNA (dsRNA)-dependent protein kinase, designated here as dsI, but also referred to as DAI, Pl kinase, p68 kinase and PI/eIF-2α protein kinase, is an interferon-induced serine/threonine protein kinase. It is uniquely distinguished from other protein kinases in that its activation to a functional enzyme, and in some cases prevention of its activation, is dependent on RNAs containing accessible double-stranded structures. However, like several other protein kinases, once activated, it elicits a modulating effect that alters cellular processes.

Keywords

Human Immunodeficiency Virus Type Eukaryotic Initiation Factor Cellular Inhibitor Interferon Action dsRNA Binding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • R. A. Petryshyn
  • J. Li
  • R. Judware
    • 1
  1. 1.Department of Biochemistry and Molecular BiologyState University of New York, Health Science Center at SyracuseSyracuseUSA

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