MHC of Nonhuman Primates
Our understanding of AIDS has been expanded by studies in nonhuman primates. Several vaccine studies in macaques have suggested that a strong immune response to SIV can be generated in appropriately immunized monkeys (Murphy-Corb et al. 1989; Desrosiers et al. 1989). Furthermore, these studies provided the first demonstration that it may be possible to induce a protective immune response against HIV. The cell-mediated immune response to SIV may prove crucial for this vaccine protection. However, to understand the nature of the cellular response to SIV in both immunized and infected monkeys, knowledge of the MHC products involved in the recognition of the virus is crucial. Indeed, in outbred populations, definition of the cellular immune response to a pathogen cannot be carried out without the knowledge of the MHC products involved.
KeywordsMajor Histocompatibility Complex Major Histocompatibility Complex Class Rhesus Monkey Nonhuman Primate Simian Immunodeficiency Virus
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