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Comparison of Regulatory Features Among Primate Lentiviruses

  • K. T. Jeang
  • A. Gatignol
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 188)

Abstract

It has been more than a decade since the description of primate lentiviruses as the etiological agents for immunodeficiencies (Barre—Sinoussi et al. 1983; Gallo et al. 1984; Levy et al. 1984; Clavel et al. 1986). Since that time, besides the human immunodeficiency viruses (HIV-1 and HIV-2), molecular isolates of simian immunodeficiency viruses (SIVs; Desrosiers 1990), as well as related viruses in cattle, cats, sheep, and goats, have been obtained. For HIVs and SIVs, extensive nucleotide sequencing information is available; the sequences from 30 or more individual HIV isolates and 20 or more SIV isolates are available in one recent compilation (Myers et al. 1992a). Based on this information, the phylogenetic relationship between (and among) HIVs and SIVs has been proposed (reviewed in Desrosiers 1990; Myers et al. 1992b). From this perspective, we can operationally categorize the primate lentiviruses into four groups, represented by (a) HIV-1 and SIVcpz; (b) SIVsmm, SIVmac, and HIV-2; (c) SIVagm; and (d) SIVmnd (Desrosiers 1990; Myers et al. 1992b).

Keywords

Human Immunodeficiency Virus Acquire Immune Deficiency Syndrome Simian Immunodeficiency Virus Deficiency Virus Type Iymphotropic Virus Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • K. T. Jeang
    • 1
  • A. Gatignol
    • 1
  1. 1.Laboratory of Molecular MicrobiologyNational Institute of Allergy and Infectious Diseases, National Institutes of HealthBethesdaUSA

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