Pathology of Simian Immunodeficiency Virus Induced Disease

  • A. A. Lackner
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 188)


Simian immunodeficiency virus (SIV) is the general name given a large family of African nonhuman primate lentiviruses which are the closest known relatives to the human immunodeficiency virus (HIV; Chakrabarti etal. 1987; Franchini et al. 1987; Hirsch et al. 1989). In their natural hosts, which include sooty mangabeys (Cercocebus atys; Fultz et al. 1986; Lowenstine et al. 1986), African green monkeys (Cercopithecus aethiops; Daniel et al. 1988; Kanki et al. 1985), mandrills (Papio sphinx; Tsujimoto et al. 1988), white-crowned mangabeys (Cercocebus torquatus lunulatus; Tomonaga et al. 1993), Sykes’ monkeys (Cercopithecus mitis albogularis; Hirsch et al. 1993), tantalus monkeys (Cercopithecus tantalus; M.C. Müller et al. 1993, and possibly other monkeys of African origin, the virus apparently exists as an exogenous, nonpathogenic infection (Desrosiers 1990). Remarkably, when SIV is introduced from one of the African nonhuman primates into an Asian macaque species, as appears to have occurred in several primate centers in the United States, an AIDS-like disease results (for review see Gardner et al. 1988).


Rhesus Macaque Simian Immunodeficiency Virus Multinucleated Giant Cell Simian Immunodeficiency Virus Infection Lymphoid Depletion 
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  1. Alpers CE, Tsai C-C, Thouless M, Kueller L, Morton WR (1988) Focal and segmental glomerulosclerosis in primates infected with simian immunodeficiency virus. Lab Invest 58: 3AGoogle Scholar
  2. Baskerville A, Ramsay A, Cranage P, Cook N, Cook RW, Dennis MJ, Greenaway PJ, Kitchin PA, Stott EJ (1990) Histopathologic changes in simian immunodeficiency virus infection. J Pathol 162: 67–75PubMedCrossRefGoogle Scholar
  3. Baskerville A, Dowsett AB, Cook RW, Dennis MJ, Cranage MP, Greenaway PJ (1991a) Pneumocystis carinii pneumonia in simian immunodeficiency virus infection: immunohistological and scanning and transmission electron microscopical studies. J Pathol 164: 175–184PubMedCrossRefGoogle Scholar
  4. Baskerville A, Ramsay A, Millwar-Sadler G, Cook R, Cranage M, Greenaway P (1991b) Chronic pancreatitis and biliary fibrosis associated with cryptosporidiosis in simian AIDS. J Comp Pathol 105: 415–42PubMedCrossRefGoogle Scholar
  5. Baskerville A, Cook RW, Dennis MJ, Cranage MP, Greenaway PJ (1992a) Pathological changes in the reproductive tract of male rhesus monkeys associated with age and simian AIDS. J Comp Pathol 107: 49–57CrossRefGoogle Scholar
  6. Baskerville A, Ramsay AD, Addis BJ, Dennis MJ, Cook RW, Cranage MP, Greenaway PJ (1992B) Interstitial pneumonia in simian immunodeficiency virus infections. J Pathol 167: 241–247PubMedCrossRefGoogle Scholar
  7. Baskin GB (1987) Disseminated cytomegalovirus infection in immunodeficient rhesus monkeys. Am J Pathol 129: 345–352PubMedGoogle Scholar
  8. Baskin GB, Martin LN, Rangan SRS, Gormus BJ, Murphey-Corb M, Wolf RH, Soike KF (1986) Transmissible lymphoma and simian acquired immunodeficiency syndrome in rhesus monkeys. J Natl Cancer Inst 77: 127–139PubMedGoogle Scholar
  9. Baskin GB, Murphey-Corb M, Watson EA, Martin LN (1988) Necropsy findings in rhesus monkeys experimentally infected with cultured simian immunodeficiency virus (SIV)/delta. Vet Pathol 25: 456–467PubMedCrossRefGoogle Scholar
  10. Baskin GB, Murphey-Corb M, Martin LN, Davison-Fairburn B, Hu F-S, Kuebler D (1991a) Thymus in simian immunodeficiency virus-infected rhesus monkeys. Lab Invest 65:400–407Google Scholar
  11. Baskin GB, Murphey-Corb M, Martin LN, Soike KF, Hu F-S, Kuebler D (1991b) Lentivirus- induced pulmonary lesions in rhesus monkeys (Macaca mulatta) infected with simian immunodeficiency virus. Vet Pathol 28: 506–513PubMedCrossRefGoogle Scholar
  12. Baskin GB, Murphey-Corb M, Roberts ED, Didier PJ, Martin LN (1992) Correlates of SIV encephalitis in rhesus monkeys. J Med Primatol 21: 59–63PubMedGoogle Scholar
  13. Benveniste RE, Arthur LO, Tsai C-C, Sowder R, Copeland TD, Henderson LE, Oroszlan S (1986) Isolation of a lentivirus from a macaque with lymphoma: comparison with HTLV-III/LAV and other lentiviruses. J Virol 60: 483–490PubMedGoogle Scholar
  14. Benveniste RE, Morton WR, Clark EA, Tsai C-C, Ochs HD, Ward JM, Kuller L, Knott WB, Hill RW, Gale MJ, Thouless ME (1988) Inoculation of baboons and macaques with simian immunodeficiency virus/Mne, a primate lentivirus closely related to human immunodeficiency virus type 2. J Virol 62: 2091–2101PubMedGoogle Scholar
  15. Blanchard JL, Baskin GB, Murphey-Corb M, Martin LN (1987) Disseminated cryptosporidiosis in simian immunodeficiency virus/delta-infected rhesus monkeys. Vet Pathol 24: 454–456PubMedGoogle Scholar
  16. Buskila D, Gladman D (1990) Musculoskeletal manifestations of infection with human immunodeficiency virus. Rev Infect Dis 12: 223–235PubMedCrossRefGoogle Scholar
  17. Chakrabarti L, Guyader M, Alizon M, Daniel MD, Desrosiers RC, Tiollais P, Sonigo P (1987) Sequence of simian immunodeficiency virus from macaque and its relationship to other human and simian retroviruses. Nature 328: 543–547PubMedCrossRefGoogle Scholar
  18. Chakrabarti L, Hurtrel M, Maaire M, Vazeux R, Dormont D, Montagnier L, Hurtrel B (1991) Early viral replication in the brain of SIV-infected rhesus monkeys. Am J Pathol 139: 1273–1280PubMedGoogle Scholar
  19. Chalifoux LV, King NW, Daniel MD, Kannagi M, Desrosiers RC, Sehgal PK, Waldron LM, Hunt RD, Letvin NL (1986) Lymphoproliferative syndrome in an immunodeficient rhesus monkey naturally infected with an HTLV-111-like virus (STLV-III). Lab Invest 55: 43–50PubMedGoogle Scholar
  20. Chalifoux LV, Ringler DJ, King NW, Sehgal PK, Desrosiers RC, Daniel MD, Letvin NL (1987) Lymphadenopathy in macaques experimentally infected with the simian immunodeficiency virus (SIV). Am J Pathol 128: 104–110PubMedGoogle Scholar
  21. Chalifoux LV, Simon MA, Pauley DR, MacKey JJ, Wyand MS, Ringler DJ (1992) Arteriopathy in macaques infected with simian immunodeficiency virus. Lab Invest 67: 338–349PubMedGoogle Scholar
  22. Cheng-Mayer C, Rutka JT, Rosenblum ML, McHugh T, Stites DP, Levy JA (1987) Human immunodeficiency virus can productively infect cultured human glial cells. Proc Natl Acad Sci USA 84. 3526–3530PubMedCrossRefGoogle Scholar
  23. Clapham PR, Weber JN, Whitby D, Mcintosh K, Dalgleish AG, Maddon PJ, Deen KC, Sweet RW, Weiss RA (1989) Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells. Nature 337: 368–370CrossRefGoogle Scholar
  24. Cockrell BY, Valerio MG, Garner FM (1974) Cryptosporidiosis in the intestines of rhesus monkeys. Lab Anim Sci 24: 881–887PubMedGoogle Scholar
  25. Dandekar S, Heise C, Vogel P, Lackner A (1993) SIV-associated intestinal abnormalities and cellular targets of SIV in the intestinal tract of rhesus macaques (Abstr. Q412). J Cell Biochem Suppl 17E: 61Google Scholar
  26. Daniel MD, Letvin NL, King NW, Kannagi M, Sehgal PK, Hunt RD, Kanki PJ, Essex M, Desrosiers RC (1985) Isolation of T-cell tropic HTLV-111-like retrovirus from macaques. Science 228: 1201–1204PubMedCrossRefGoogle Scholar
  27. Daniel MD, Li Y, Naidu YM, Durda PJ, Schmidt DK, Finger CD, Silva DP, MacKey JJ, Kestler HW, Sehgal PK, King NW, Hayami M, Desrosiers RC (1988) Simian immunodeficiency viruses from African green monkeys. J Virol 62: 4123–4128PubMedGoogle Scholar
  28. Desrosiers RC (1990) The simian immunodeficiency viruses. Annu Rev Immunol 8: 557–578PubMedCrossRefGoogle Scholar
  29. Desrosiers RC, Letvin NL, King NW, Hunt RD, Blake BJ, Arthur LO, Daniel MD (1987) Three retroviruses infecting macaques at the New England Regional Primate Research Center. In: Gallo RC, Haseltine W, Klein G, zurHausen H (eds) Viruses and human cancer. Liss, New York, pp 451–466Google Scholar
  30. Desrosiers RC, Hansen-Moosa A, Mori K, Bouvier DP, King NW, Daniel MD, Ringler DJ (1991) Macrophage-tropic variants of SIV are associated with specific AIDS-related lesions but are not essential for the development of AIDS. Am J Pathol 139: 29–35PubMedGoogle Scholar
  31. Embretson J, Zupancic M, Ribas JL, Burke A, Racz P, Tenner-Racz K, Haase AT (1993) Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362: 359–362PubMedCrossRefGoogle Scholar
  32. Epstein LG (1989) Lentiviral encephalitides in the immature host: a comparison of human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) brain infection. Brain Dev 11: 353–359PubMedGoogle Scholar
  33. Feichtinger H, Putkonen P, Parravicini C, Li SL, Kaaya EE, Böttiger D, Biberfeld G, Biberfeld P (1990) Malignant lymphomas in cynomolgus monkeys infected with simian immunodeficiency virus. Am J Pathol 137: 1311–1315PubMedGoogle Scholar
  34. Fox CH, Tenner-Racz K, Racz P, Firpo A, Pizzo PA, Fauci AS (1991) Lymphoid germinal centers are reservoirs of human immunodeficiency virus type 1 RNA. J Infect Dis 164: 1051–1057PubMedCrossRefGoogle Scholar
  35. Franchini G, Gurgo C, Guo HG, Gallo RC, Collalti E, Fargnoli KA, Hall LF, Wong-Staal F, Reitz MSJ (1987) Sequence of simian immunodeficiency virus and its relationship to the human immunodeficiency viruses. Nature 328: 539–543PubMedCrossRefGoogle Scholar
  36. Fultz PN, McClure H, Anderson DC, Swenson RB, Anand R, Srinivasan A (1986) Isolation of a T-lymphotropic retrovirus from naturally infected sooty mangabey monkeys (Cercocebus atys).Proc Natl Acad Sci USA 83: 5286–5290PubMedCrossRefGoogle Scholar
  37. Fultz PN, McClure HM, Anderson DC, Switzer WM (1989) Identification and biologic characterization of an acutely lethal variant of simian immunodeficiency virus from sooty mangabeys (SIV/SMM). Aids Res Hum Retroviruses 5: 397–409PubMedCrossRefGoogle Scholar
  38. Gardner MB, Luciw P, Lerche N, Marx P (1988) Non-human primate retrovirus isolates and AIDS. In: Perk K (ed) Immunodeficiency disorders and AIDS. Academic Press, New York, pp 171–226Google Scholar
  39. Gerber M, Chen M, Hu F, Baskin G, Petrovich L (1991) Liver disease in rhesus monkeys infected with simian immunodeficiency virus. Am J Pathol 139: 1081–1088PubMedGoogle Scholar
  40. Gribble DH, Haden CC, Schwartz LW, Henrickson RV (1975) Spontaneous progressive multifocal leukoencephalopathy (PML) in macaques. Nature 254: 602–604PubMedCrossRefGoogle Scholar
  41. Haase AT (1986) Pathogenesis of lentivirus infections. Nature 322: 130–136PubMedCrossRefGoogle Scholar
  42. Heise C, Vogel P, Miller CJ, Halsted CH, Dandekar S (1993a) Simian immunodeficiency virus infection of the gastrointestinal tract of rhesus macaques: functional, pathological and morphological changes. Am J Pathol 142: 1–13Google Scholar
  43. Heise C, Vogel P, Miller CJ, Lackner AA, Dandekar S (1993b) Distribution of SIV infection in the gastrointestinal tract of rhesus macaques at early and terminal stages of AIDS. J Med Primatol (in press)Google Scholar
  44. Hirsch VM, Olmsted RA, Murphey-Corb M, Purcell RH, Johnson PR (1989) An African primate lentivirus (SIVsm) closely related to HIV-2. Nature 339: 389–392PubMedCrossRefGoogle Scholar
  45. Hirsch VM, Dapolito GA, Goldstein S, McClure H, Emau P, Fultz PN, Isahakia M, Lenroot R, Myers G, Johnson PR (1993) A distinct African lentivirus from Sykes’ monkeys. J Virol 67: 1517–1528PubMedGoogle Scholar
  46. Holmberg CA, Gribble DH, Takemoto KK, Howley PM, Espana C, Osburn Bl (1977) Isolation of simian virus 40 from rhesus monkeys (Macaca mulatta) with spontaneous progressive multifocal leukoencephalopathy. J Infect Dis 136: 593–596PubMedCrossRefGoogle Scholar
  47. Holmberg CA, Henrickson RV, Malaga C, Schneider R, Gribble D (1982) Nontuberculous mycobacterial disease in rhesus monkeys. Vet Pathol 19 Suppl 7: 9–16CrossRefGoogle Scholar
  48. Holmberg CA, Henrickson R, Lenninger R, Anderson J, Hayashi L, Ellingsworth L (1985) Immunologic abnormality in a group of Macaca arctoides with high mortality due to a typical mycobacterial and other disease processes. Am J Vet Res 46: 1192–1196PubMedGoogle Scholar
  49. Horvath CJ, Simon MA, Bergsagel DJ, Pauley DR, King NW, Garcea RL, Ringler DJ (1992) Simian virus 40-induced disease in rhesus monkeys with simian acquired immunodeficiency syndrome. Am J Pathol 140: 1431–1440PubMedGoogle Scholar
  50. Israel ZR, Dean GA, Maul DH, O’Neil SP, Dreitz MJ, Mullins Jl, Fultz PN, Hoover EA (1993) Early pathogenesis of disease caused by SIVsmm PBj14 molecular clone 1.9 in macaques. Aids Res Hum Retroviruses 9: 277–286PubMedCrossRefGoogle Scholar
  51. Joling P, Van Wichen DF, Parmentier HK, Biberfeld P, Böttiger D, Tschopp J, Rademakers LHPM, Schuurman HJ (1992) Simian immunodeficiency virus (SIVsm) infection of cynomolgus monkeys: effects on follicular dendritic cells in lymphoid tissue. Aids Res Hum Retroviruses 8: 2021–2030PubMedCrossRefGoogle Scholar
  52. Joshi W, Path FRC, Pawel B, Connor E, Sharer L, Oleske JM, Morrison S, Marin-Garcia J (1987) Arteriopathy in children with acquired immune deficiency syndrome. Pediatr Pathol 7: 261–275PubMedCrossRefGoogle Scholar
  53. Kahn A, Galvin T, Lowenstine L, Jennings M, Gardner M, Buckler C (1991) A highly divergent simian immunodeficiency virus (SIVstm) recovered from stored stump-tailed macaque tissues. J Virol 65: 7061–7065Google Scholar
  54. Kanki PJ, Alroy J, Essex M (1985) Isolation of T-lymphotropic retrovirus related to HTLV- III/LAV from wild-caught african green monkeys. Science 230: 951–954PubMedCrossRefGoogle Scholar
  55. King NW, Chalifoux LV, Ringler DJ, Wyand MS, Sehgal PK, Daniel MD, Letvin NL, Desrosiers RC, Blake BJ, Hunt RD (1990) Comparative biology of natural and experimental SIVmac infection of macaque monkeys: a review. J Med Primatol 19: 109–118PubMedGoogle Scholar
  56. Kitagawa M, Lackner AA, Martfeld DJ, Gardner MB, Dandekar S (1991) Simian immunodeficiency virus infection of bone marrow: correlation of viral infection with disease progression and hematologic abnormalities. Am J Pathol 138: 921–930PubMedGoogle Scholar
  57. Klatzmann D, Barre-Sinoussi F, Nugeyre MT, Danguet C, Vilmer C, Griscelli C, Brun-Vézinet F, Rouzioux C, Gluckman JC, Cherman JC, Montagnier L (1984) Selective tropism of lymphadenopathy associated virus (LAV) for helper-induced T-lymphocytets. Science 225: 59–63PubMedCrossRefGoogle Scholar
  58. Kovatch RM, White JD (1972) Cryptosporidiosis in two juvenile rhesus monkeys. Vet Pathol 9: 426–440Google Scholar
  59. Kuller L, Morton WR, Benveniste RE, Tsai CC, Clark EA, Gale MJ, Hu SL, Thouless ME, Katze MG (1990) Inoculation of Macacafascicularis with simian immunodeficiency virus, SIVmne: immunologic, serologic, and pathologic changes. J Med Primatol 19: 367–380PubMedGoogle Scholar
  60. Kunsch C, Hartle HT, Wigdahl B (1989) Infection of human fetal dorsal root ganglion glial cells with human immunodeficiency virus type 1 involves an entry mechanism independent of the CD4 T4A epitope. J Virol 63: 5054–5061PubMedGoogle Scholar
  61. Lackner AA, Moore PF, Marx PA, Munn RJ, Gardner MB, Lowenstine LJ (1990) Immunohistochemical localization of type D retrovirus serotype 1 in the digestive tract of rhesus monkeys with simian AIDS. J Med Primatol 19: 339–349PubMedGoogle Scholar
  62. Lackner AA, Dandekar S, Gardner MB (1991a) Neurobiology of simian and feline immunodeficiency virus infections. Brain Pathol 1: 201–212PubMedCrossRefGoogle Scholar
  63. Lackner AA, Smith MO, Munn RJ, Martfeld DJ, Gardner MB, Marx PA, Dandekar S (1991b) Localization of simian immunodeficiency virus in the central nervous system of rhesus monkeys. Am J Pathol 139: 609–621PubMedGoogle Scholar
  64. Lackner AA, Vogel P, Hoogenboom E, Dandekar S, Kluge JD, Marthas M (1991c) Pathogenic (SIVmac-239) and nonpathogenic (SIVmac-1 A11) molecular clones of SIV have distinct tissue distributions that vary with length of infection. 9th Annual Symposium on Nonhuman Primate Models for AIDS, Nov 6–9, SeattleGoogle Scholar
  65. Letvin NL, King NW (1990) Immunologic and pathologic manifestations of infection of rhesus monkeys with simian immunodeficiency virus of macaques. J Acquir Immune Defic Syndr 3: 1023–1040PubMedGoogle Scholar
  66. Letvin NL, Daniel MD, Sehgal PK, Desrosiers RC, Hunt RD, Waldron LM, MacKey JJ, Schmidt DK, Chalifoux LV, King NW (1985) Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III. Science 230: 71–73PubMedCrossRefGoogle Scholar
  67. Lowenstine LJ, Pedersen NC, Higgins J, Pallis KC, Uyeda A, Marx PA, Lerche NW, Munn RJ, Gardner MB (1986) Seroepidemiologic survey of captive old-world primates for antibodies to human and simian retroviruses and isolation of a lentivirus from sooty mangabeys (Cercocebus atys). Int J Cancer 38: 563–574PubMedCrossRefGoogle Scholar
  68. Lowenstine LJ, Lerche NW, Yee JL, Uyeda A, Jennings MB, Munn RJ, McClure HM, Anderson DC, Fultz PN, Gardner MB (1992) Evidence for a lentiviral etiology in an epizootic of immune deficiency and lymphoma in stump-tailed macaques (Macaca arctoides). J Med Primatol 21: 1–14PubMedGoogle Scholar
  69. Manning JS, Griesemer RA (1974) Spontaneous lymphoma of the nonhuman primate. Lab Anim Sci 24: 204–210PubMedGoogle Scholar
  70. Marx PA, Maul DH, Osborn KG, Lerche NW, Moody P, Lowenstine LJ, Henrickson RV, Arthur L0, Gravell M, London WT, Sever JL, Levy JA, Munn RJ, Gardner MB (1984) Simian AIDS: isolation of a type D retrovirus and disease transmission. Science 223: 1083–1086PubMedCrossRefGoogle Scholar
  71. Miller CJ, Vogel P, Alexander NJ, Sutjipto S, Hendrickx AG, Marx PA (1992) Localization of SIV in the genital tract of chronically infected female rhesus macaques. Am J Pathol 141: 655–660PubMedGoogle Scholar
  72. Miller RA, Brondson MA, Kuller L, Morton WR (1990a) Clinical and parsitologic aspects of cryptosporidiosis in nonhuman primates. Lab Anim Sci 40: 42–46PubMedGoogle Scholar
  73. Miller RA, Brondson MA, Morton WR (1990b) Experimental cryptosporidiosis in a primate model. J Infect Dis 161: 312–315PubMedCrossRefGoogle Scholar
  74. Müller H, Weier S, Kojouharoff G, Grez M, Berger S, Kappus R, Shah PM, Stutte HJ, Schmidts HL (1993) Distribution and infection of Langerhans cells in the skin of HIV-infected healthy subjects and AIDS patients. Res Virol 144: 59–67PubMedCrossRefGoogle Scholar
  75. Müller MC, Saksena NK, Nerrienet E, Chappey C, Hervé VMA, Durand JP, Legal-Compodonico P, Lang MC, Digoutte JP, Georges AJ, Georges-Courbot MC, Sonigo P, Barré-Sinoussi F (1993) Simian immunodeficiency viruses from central and western Africa. J Virol 67: 1227–1235PubMedGoogle Scholar
  76. Murray JF, Mills J (1990a) Pulmonary infectious complications of human immunodeficiency virus infection. Part I. Am Rev Respir Dis 1: 1356–1372Google Scholar
  77. Murray JF, Mills J (1990b) Pulmonary infectious complications of human immunodeficiency virus infection. Part II. Am Rev Respir Dis 141: 1582–1598PubMedGoogle Scholar
  78. Nelson JA, Wiley CA, Reynolds-Kohler C, Reese CE, Margetten W, Levy JA (1988) Human immunodeficiency virus detected in bowel epithelium from patients with gastrointestinal symptoms. Lancet: 259–262Google Scholar
  79. Ormerod LD, Osborn KG, Lowenstine LJ, Meyer PR, Parker JW, Smith RE, Taylor CR (1988) Lymphoid immunohistochemistry of macaque primates. Clin Exp Immunol 74: 435–442PubMedGoogle Scholar
  80. Osborn KG, Prahalada S, Lowenstine LJ, Gardner MB, Maul DH, Henrickson RV (1984) The pathology of an epizootic of acquired immunodeficiency in rhesus macaques. Am J Pathol 114: 94–103PubMedGoogle Scholar
  81. Pantaleo G, Graziosi C, Demarest JF, Butini L, Montroni M, Fox CH, Orenstein JM, Kotler DP, Fauci AS (1993) HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362: 355–358PubMedCrossRefGoogle Scholar
  82. Price RW, Brew B, Sidtis J, Rosenblum M, Scheck AC, Cleary P (1988) The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science 239:586–592PubMedCrossRefGoogle Scholar
  83. Ramsay AD, Giddings J, Baskerville A, Cranage MP (1991) Phenotypic analysis of malignant lymphoma in simian immunodeficiency virus infection using anti-human antibodies. J Pathol 164: 321–328PubMedCrossRefGoogle Scholar
  84. Rangan SRS, Martin LN, Bozelka BE, Wang N, Gormus BJ (1986) Epstein-Barr virus-related herpesvirus from a rhesus monkey(Macaca mu/atta) with malignant lymphoma. Int J Cancer 38: 425–432PubMedCrossRefGoogle Scholar
  85. Rappersberger K, Gartner S, Schenk P, Stingl G, Groh V, Tschachler E, Mann DL, Wolff K, Konrad K, Popvic M (1988) Langerhans’ cells are an actual site of HIV-1 replication Intervirology 29: 185–194Google Scholar
  86. Reinacher M (1987) Feline leukemia virus-associated enteritis-a condition with features of feline panleukopenia. Vet Pathol 24: 1–4PubMedGoogle Scholar
  87. Ringler DJ, Murphy GF, King NW (1986) An erythematous maculopapular eruption in macaques infected with an HTLV-Ill-like virus (STLV-III). J Invest Dermatol 87: 674–677PubMedCrossRefGoogle Scholar
  88. Ringler DJ, Hancock WW, King NW, Letvin NL, Daniel MD, Desrosiers RC, Murphy GF (1987) Immunophenotypic characterization of the cutaneous exanthem of SIV-infected rhesus monkeys: apposition of degenerative Langerhans cells and cytotoxic lymphocytes during the development of acquired immunodeficiency syndrome. Am J Pathol 126: 199–207PubMedGoogle Scholar
  89. Ringler DJ, Wyand MS, Walsh DG, MacKey JJ, Chalifoux LV, Popovic M, Minassian AA, Sehgal PK, Daniel MD, Desrosiers RC, King NW (1989) Cellular localization of simian immunodeficiency virus in lymphoid tissues. I. Immunohistochemistry and electron microscopy. Am J Pathol 134: 373–383PubMedGoogle Scholar
  90. Roberts E, Martin L (1991) Arthritis in rhesus monkeys experimentally infected with simian immunodeficiency virus (SIV/delta). Lab Invest 65: 637–643PubMedGoogle Scholar
  91. Sasseville VG, Newman WA, Lackner AA, Smith MO, Lausen NC, Beall D, Ringler DJ (1992) Elevated vascular cell adhesion molecule-1 in AIDS encephalitis induced by simian immunodeficiency virus. Am J Pathol 141: 1021–30PubMedGoogle Scholar
  92. Sharer LR, Epstein LG, Cho E-S, Joshi VV, Meyenhofer MF, Rankin LF, Petito CK (1986) Pathologic features of AIDS encephalopathy in children: evidence for LAV/HTLV-III infection of the brain. Hum Pathol 17: 271–284PubMedCrossRefGoogle Scholar
  93. Sharer LR, Michaels J, Murphey-Corb H, Hu F-S, Kuebler DJ, Martin LN, Baskin GB (1991) Serial pathogenesis study of SIV brain infection. J Med Primatol 20: 211–217PubMedGoogle Scholar
  94. Sheffield WD, Strandberg JD, Braun L, Shah K, Kalter SS (1980) Simian virus 40-associated fatal interstitial pneumonia and renal tubular necrosis in a rhesus monkey. J Infect Dis 142: 618–622PubMedCrossRefGoogle Scholar
  95. Simon MA, Chalifoux LV, Ringler DJ (1992) Pathologic features of SIV-induced disease and the association of macrophage infection with disease evolution. Aids Res Hum Retroviruses 8: 327–337PubMedCrossRefGoogle Scholar
  96. Stowell RC, Smith EK, Espana C, Nelson VG (1971) Outbreak of malignant lymphoma in rhesus monkeys. Lab Invest 25: 476–479PubMedGoogle Scholar
  97. Terrell TG, Gribble DH, Osburn Bl (1980) Malignant lymphoma in macaques: a clinicopathologic study of 45 cases. J Natl Cancer Inst 64: 561–568PubMedGoogle Scholar
  98. Tomonaga K, Katahira J, Fukasawa M, Hassan MA, Kawamura M, Akari H, Miura T, Goto T, Nakai M, Suleman M, Isahakia M, Hayami M (1993) Isolation and characterization of simian immunodeficiency virus from African white-crowned mangabey monkeys (Cercocebus torquatus lunulatus). Arch Virol 129: 77–92PubMedCrossRefGoogle Scholar
  99. Tschachler E, Groh V, Popvic M, Mann DL, Konrad K, Safai B, Eron L, diMarzo-Veronese F, Wolff K, Stingl G (1987) Epidermal Langerhans cells: a target for HTLV-III/LAV infection. J Invest Dermatol 88: 233–237PubMedCrossRefGoogle Scholar
  100. Tsujimoto H, Cooper RW, Kodama T, Fukasawa M, Miura T, Ohta Y, Ishikawa K-l, Frost E, Roelents GE, Nakai M, Roff J, Hayami M (1988) Isolation and characterization of simian immunodeficiency virus from mandrills in Africa and its relationship to other human and simian immunodeficiency viruses. J Virol 62: 4044–4050PubMedGoogle Scholar
  101. Vogel P, Lackner AA, Alcendor DJ, Dandekar S (1991) Distribution of rhesus cytomegalovirus (CMV) and simian immunodeficiency virus (SIV) in lungs of rhesus macaques (Absh). Lab Invest 64: 90AGoogle Scholar
  102. Vogel P, Miller CJ, Lowenstine L, Lackner A (1993) Evidence of horizontal transmission of Pneumocystis carinii pneumonia in SIV-infected rhesus macaques. J Infect Dis (in press)Google Scholar
  103. Watanabe M, Ringler DJ, Nakamura M, DeLong PA, Letvin NL (1990) Simian immunodeficiency virus inhibits bone marrow hematopoietic progenitor cell growth. J Virol 64: 656–663PubMedGoogle Scholar
  104. Weigler BJ, Roberts JA, Hird DW, Lerche NW, Hilliard JK (1990) A cross sectional survey for B virus antibody in a colony of group housed rhesus macaques. Lab Anim Sci 40: 257–261PubMedGoogle Scholar
  105. Wilson DW, Day PA, Brummer MEG (1984) Diarrhea associated with Cryptosporidium spp in juvenile macaques. Vet Pathol 21: 447–450PubMedGoogle Scholar
  106. Wyand MS, Ringler DJ, Naidu YM, Mattmuller M, Chalifoux LV, Sehgal PK, Daniel MD, Desrosiers RC, King NW (1989) Cellular localization of simian immunodeficiency virus in lymphoid tissues. II. In situ hybridization. Am J Pathol 134: 385–393PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • A. A. Lackner
    • 1
  1. 1.California Regional Primate Research Center and Department of Veterinary PathologyUniversity of CaliforniaDavisUSA

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