Pathology of Simian Immunodeficiency Virus Induced Disease

  • A. A. Lackner
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 188)

Abstract

Simian immunodeficiency virus (SIV) is the general name given a large family of African nonhuman primate lentiviruses which are the closest known relatives to the human immunodeficiency virus (HIV; Chakrabarti etal. 1987; Franchini et al. 1987; Hirsch et al. 1989). In their natural hosts, which include sooty mangabeys (Cercocebus atys; Fultz et al. 1986; Lowenstine et al. 1986), African green monkeys (Cercopithecus aethiops; Daniel et al. 1988; Kanki et al. 1985), mandrills (Papio sphinx; Tsujimoto et al. 1988), white-crowned mangabeys (Cercocebus torquatus lunulatus; Tomonaga et al. 1993), Sykes’ monkeys (Cercopithecus mitis albogularis; Hirsch et al. 1993), tantalus monkeys (Cercopithecus tantalus; M.C. Müller et al. 1993, and possibly other monkeys of African origin, the virus apparently exists as an exogenous, nonpathogenic infection (Desrosiers 1990). Remarkably, when SIV is introduced from one of the African nonhuman primates into an Asian macaque species, as appears to have occurred in several primate centers in the United States, an AIDS-like disease results (for review see Gardner et al. 1988).

Keywords

Arthritis Hepatitis Pneumonia Adenoma Dementia 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • A. A. Lackner
    • 1
  1. 1.California Regional Primate Research Center and Department of Veterinary PathologyUniversity of CaliforniaDavisUSA

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