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Cytotoxic T Lymphocytes Specific for Influenza Virus

  • A. McMichael
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 189)

Abstract

Influenza virus has proved an excellent model for the study of the specificity of cytotoxic T lymphocytes (CTL) and of the processing of viral antigens. Fundamental information about these processes has been gained in both mice and humans. At the same time, a considerable amount has been learned about the role of CTL in influenza viral infections, particularly in mice. The virus has proved to be a malleable tool because it can be readily grown, the full nucleotide structure has been determined (in the 1970s; reviewed in Lamb 1983), there are multiple antigenic variants, many of which have been sequenced, the three-dimensional structures of haemagglutinin and neuraminidase are known (Varghese et al. 1983; Wiley et al. 1981) and, for human studies, it has the advantage that it has infected a very high percentage of the population. All of these features combine to make this a safe and invaluable model for the study of theoretical aspects of T cell function as well as investigating the practical issues of how T cells control virus infections. Studies with influenza virus answered long-standing questions about the interaction between viral antigens and class I molecules of the major histocompatibility complex (MHC). Along the way came information about mutant and variant MHC molecules and the demonstration that peptide epitopes presented by class I MHC molecules are recognised by CTL. More recently, the virus has been invaluable for the elucidation of the antigenprocessing pathways.

Keywords

Influenza Virus Internal Virus Protein Influenza Nucleoprotein Cerundolo Versus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • A. McMichael
    • 1
  1. 1.Institute of Molecular MedicineJohn Radcliffe HospitalOxfordUK

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