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Cytotoxic T Lymphocytes in Humans Exposed to Plasmodium falciparum by Immunization or Natural Exposure

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Cytotoxic T-Lymphocytes in Human Viral and Malaria Infections

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 189))

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Abstract

Malaria is one of the most important infectious diseases in the world. It is estimated that 2.1 billion people live in areas of the world where malaria is transmitted and that there are 100–300 million new cases of malaria and one to two million deaths caused by malaria every year (WHO 1991). In the past 10–20 years, the severity of the malaria problem has worsened in many areas because of the emergence of drug-resistant strains of the parasite, resistance to insecticides of the Anopheles sp. mosquitoes that transmit the disease, socioeconomic problems that have led to a decreased capacity to optimally utilize existing tools to combat the disease, and movement of nonimmune populations into areas where malaria is transmitted. Accordingly, there are now renewed efforts to control this disease. A major focus of research efforts is to develop vaccines against malaria, including vaccines designed to produce protective cytotoxic T lymphocytes (CTL; Hoffman et al. 1991). To understand how such vaccines might work, it is important to understand the life cycle of the parasite.

The opinions and assertions herein are the private ones of the authors and are not to be construed as official or as reflecting the views of the U.S. Navy or the Naval Service at large.

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Authors and Affiliations

  1. Malaria Program, Naval Medical Research Institute, Bethesda, MD, 20889-5607, USA

    S. L. Hoffman, M. Sedegah & A. Malik

  2. Pan American Health Organization, Washington DC, 20037, USA

    M. Sedegah

Authors
  1. S. L. Hoffman
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  2. M. Sedegah
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  3. A. Malik
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Editors and Affiliations

  1. Department of Neuropharmacology Division of Virology, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA

    Michael B. A. Oldstone

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© 1994 Springer-Verlag Berlin Heidelberg

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Hoffman, S.L., Sedegah, M., Malik, A. (1994). Cytotoxic T Lymphocytes in Humans Exposed to Plasmodium falciparum by Immunization or Natural Exposure. In: Oldstone, M.B.A. (eds) Cytotoxic T-Lymphocytes in Human Viral and Malaria Infections. Current Topics in Microbiology and Immunology, vol 189. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78530-6_11

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  • DOI: https://doi.org/10.1007/978-3-642-78530-6_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78532-0

  • Online ISBN: 978-3-642-78530-6

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