Macrophage Activity, Fibronectin, and SPARC Protein in Experimentally Induced Granuloma
Repair of injured tissue is a sequence of events in which cells with distinct functions are attached to the wound, proliferate, and secrete extracellular matrix material to finally restore structure and function.
KeywordsMigration Cysteine Sponge Gelatin Hematoxylin
Unable to display preview. Download preview PDF.
- 1.Shoshan S (1981) Wound healing. Int Rev Connect Tissue Res 9: 1–26Google Scholar
- 2.Clark RA, Henson PM (eds) (1988) Molecular and cellular biology of wound repair. Plenum, New YorkGoogle Scholar
- 3.Wahl SM, Wahl LM (1981) Modulation of fibroblast growth and function by monokines and lymphokines. Lymphokines, vol 2: A forum for immunoregulatory cell products, p 179Google Scholar
- 5.Werb Z, Gordon S (1975) Elastase secretion by stimulated macrophages. Characterization and regulation. J Exp Med 142: 361–377Google Scholar
- 12.Deno DC, McCafferty MH, Saba TM, Blumenstock FA (1984) Mechanism of acute depletion of plasma fibronectin following thermal injury in rats. Appearance of a gelatin like ligand in plasma. J Clin Invest 73: 20–34Google Scholar
- 14.Nagelschmidt M, Becker D, Bonninghoff N, Engelhardt GH (1987) Effect of fibronectin therapy and fibronectin deficiency on wound healing: a study in rats. J Trauma 27:1267– 1271Google Scholar
- 16.Grinnell F, Geiger B (1986) Interaction of fibronectin–coated beads with attached and spread fibroblasts. Binding, phagocytosis, and cytoskeletal reorganization. Exp Cell Res 162: 449–461Google Scholar
- 18.Mason IJ, Taylor A, Williams JG, Sage EH, Hogan BL (1986) Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell ‘culture shock’ glycoprotein of Mr 43000. EMBO J 5: 1465–1472Google Scholar