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Investigations of Cell Cultures Derived from Patients Suffering from Dupuytren’s Contracture

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Dupuytren’s Disease

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Abstract

Comparative cell cultures derived from biopsies of healthy subjects and patients suffering from disease allow one to study permanent alterations on the cellular level. The isolation of cells and their subcultivation shock the cells and alter their behavior with respect to a transition from the resting to the cycling state of the cell cycle. This is, at least in part, due to the loss of contact inhibition by elements of the extracellular matrix (ECM) and other cells in the vicinity; nonetheless, many of the features of cultured cells still correspond to their in vivo situation. Cultured cells derived postoperatively from patients start their proliferation from a certain stage of disease, which is characterized by the distribution of different cell types and their functions.

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Authors
  1. J. Neumüller
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Editors and Affiliations

  1. Klinik für Plastische, Hand- und Wiederherstellungschirurgie, Krankenhaus Oststadt, Medizinische Hochschule Hannover, Podielskistraße 380, 30659, Hannover, Germany

    Alfred Berger  & Peter Brenner  & 

  2. Institut für Klinische Chemie II, Krankenhaus Oststadt, Medizinische Hochschule Hannover, Podbielskistraße 380, 30659, Hannover, Germany

    Axel Delbrück  & Rolf Hinzmann  & 

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© 1994 Springer-Verlag Berlin Heidelberg

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Neumüller, J. (1994). Investigations of Cell Cultures Derived from Patients Suffering from Dupuytren’s Contracture. In: Berger, A., Delbrück, A., Brenner, P., Hinzmann, R. (eds) Dupuytren’s Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78517-7_11

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  • DOI: https://doi.org/10.1007/978-3-642-78517-7_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-57239-8

  • Online ISBN: 978-3-642-78517-7

  • eBook Packages: Springer Book Archive

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