Investigations of Cell Cultures Derived from Patients Suffering from Dupuytren’s Contracture

  • J. Neumüller
Conference paper


Comparative cell cultures derived from biopsies of healthy subjects and patients suffering from disease allow one to study permanent alterations on the cellular level. The isolation of cells and their subcultivation shock the cells and alter their behavior with respect to a transition from the resting to the cycling state of the cell cycle. This is, at least in part, due to the loss of contact inhibition by elements of the extracellular matrix (ECM) and other cells in the vicinity; nonetheless, many of the features of cultured cells still correspond to their in vivo situation. Cultured cells derived postoperatively from patients start their proliferation from a certain stage of disease, which is characterized by the distribution of different cell types and their functions.


Carpal Tunnel Syndrome Collagen Fibril Hallux Valgus Plate Efficiency Exocytotic Vesicle 
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© Springer-Verlag Berlin Heidelberg 1994

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  • J. Neumüller

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