Morphology of Dupuytren’s Disease

  • W. Mohr
  • D. Wessinghage


Dupuytren’s disease has a prevalence of 1%–3% (Viljanto 1973) and usually occurs in middle aged or elderly men (gt;40 years). Females suffer much less frequently from this disorder (Fig. 1), as shown by Yost et al. (1955), who found a male:female ratio of 3:1. Although there is an often mentioned “causal” association with diabetes mellitus (Pal et al. 1987), this is not etiologically significant.


Mast Cell Carpal Tunnel Syndrome Collagenous Fibril Prussian Blue Smooth Muscle Actin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Allen PW (1977) The fibromatoses: a clinicopathologic classification based on 140 cases. Am J Surg Pathol 1: 255–270PubMedCrossRefGoogle Scholar
  2. Andrew JG, Ash A, Turner B, Andrew SM (1990) The role of inflammatory cells in Dupuytrens contracture: an immunohistochemical study ( Abstr ). J Bone Joint Surg [Br] 72: 1110Google Scholar
  3. Azizkhan RG, Clifford Azizkhan J, Zetter BR, Folkman J (1980) Mast cell heparin stimulates migration of capillary endothelial cells in vitro. J Exp Med 152: 931–944PubMedCrossRefGoogle Scholar
  4. Beranek JT, Cavarocchi NC (1990) Histogenesis of the intimal thickening in atherosclerosis and of hyperplastic processes in connective tissue. Hum Pathol 21: 1082–1083PubMedCrossRefGoogle Scholar
  5. Brax P (1992) Pathologisch-anatomische und pathogenetische Aspekte der pigmentierten villomodularen Synovialitis. Medical dissertation, University of UlmGoogle Scholar
  6. Brooks J J (1986) The significance of double phenotypic patterns and markers in human sarcomas. A new model of mesenchymal differentiation. Am J Pathol 125: 113–123PubMedGoogle Scholar
  7. Claman HN (1989) Mast cell changes in a case of rapidly progressive scleroderma - ultrastructural analysis. J Invest Dermatol 92: 290–295PubMedCrossRefGoogle Scholar
  8. Diaz-Flores L, Dominguez C (1985) Relation between arterial intimal thickening and the vasa-vasorum. Virchows Arch [A] 406: 165–177CrossRefGoogle Scholar
  9. Druvefors P, Norrby K (1988) Molecular aspects of mast-cell-mediated mitogenesis in fibroblasts and mesothelial cells in situ. Virchows Arch [Cell Pathol] 55: 187–192Google Scholar
  10. Falanga V, Soter NA, Altaian RD, Kerdel FA (1990) Elevated plasma histamine levels in systemic sclerosis (scleroderma). Arch Dermatol 126: 336–338PubMedCrossRefGoogle Scholar
  11. Ghadially FN (1983) Fine structure of synovial joints. Butterworth, LondonGoogle Scholar
  12. Hatamochi A, Fuji war a K, Ueki H (1985) Effects of histamine on collagen synthesis by cultured fibroblasts derived from guinea pig skin. Arch Dermatol Res 277: 60–64Google Scholar
  13. Krsti RV (1984) Illustrated encyclopedia of human histology. Springer, Berlin Heidelberg New YorkGoogle Scholar
  14. Luck JV (1959) Dupuytren’s contracture. J Bone Joint Surg [Am] 41: 635–664Google Scholar
  15. Marks RM, Roche WR, Czerniecki M, Penny R, Nelson DS (1986) Mast cell granules cause proliferation of human microvascular endothelial cells. Lab Invest 55: 289–294PubMedGoogle Scholar
  16. Mechtersheimer G, Moller P (1990) Expression of Ki-1 antigen (CD30) in mesenchymal tumors. Cancer 66: 1732–1737PubMedCrossRefGoogle Scholar
  17. Meister P, Gokel JM, Remberger K (1979) Palmar fibromatosis - “Dupuytren’s contracture”. A comparison of light electron and immunofluorescent microscopic findings. Pathol Res Pract 16: 402–412Google Scholar
  18. Mohr W (1983) Pathologie der Dupuytren’schen Krankheit. Med Welt 34: 397–404PubMedGoogle Scholar
  19. Mohr W (1987) Pathologie des Bandapparates. Sehnen, Sehnenscheiden, Faszien, Schleimbeutel. In: Doerr W, Seifert G (eds) Spezielle pathologische Anatomie, vol 19. Springer, Berlin Heidelberg New YorkGoogle Scholar
  20. Mohr W, Vossbeck G (1985) Untersuchungen zur Proliferation und 3H-Prolin-Inkorporation von Zellen der Palmarfibromatose ( Morbus Dupuytren ). Z Rheumatol 44: 226–230Google Scholar
  21. Murrell GAC, Francis MJO, Howlett CR (1989) Dupuytren’s contracture. Fine structure in relation to aetiology. J Bone Joint Surg [Br] 71: 367–373Google Scholar
  22. Pal B, Griffiths ID, Anderson J, Dick WC (1987) Association of limited joint mobility with Dupuytren’s contracture in diabetes mellitus. J Rheumatol 14: 582–585PubMedGoogle Scholar
  23. Roholl PJM, Elbers HR, Prinsen I, Claessens JAJ, van Unnik JAM (1990) Distribution of actin isoforms in sarcomas: an immunohistochemical study. Hum Pathol 21: 1269–1274PubMedCrossRefGoogle Scholar
  24. Sandberg N (1962) Accelerated collagen formation and histamine. Nature 194: 183PubMedCrossRefGoogle Scholar
  25. Sarkisov DS, Kolocolchicova EG, Varava BN, Tjurmin AV, Peclo MM, Printseva OY (1989) Morphogenesis of intimal thickening in nonspecific aortoarteritis. Hum Pathol 20: 1048–1056PubMedCrossRefGoogle Scholar
  26. Skalli O, Schiirch W, Seemayer T, Lagace R, Montandon D, Pittet B, Gabbiani G (1989) Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins. Lab Invest 60: 275–285PubMedGoogle Scholar
  27. Stout AP, Murray MR (1942) Hemangiopericytoma. A vascular tumor featering Zimmermanns’ pericytes. Ann Surg 116: 26–33Google Scholar
  28. Tomasek JJ, Schultz RJ, Haaksma CJ (1987) Extracellular matrix–cytoskeletal connections at the surface of the specialized contractile fibroblast (myofibroblast) in Dupuytren disease. J Bone Joint Surg [Am] 69: 1400–1407Google Scholar
  29. Ushijima M, Tsuneyoshi M, Enjoji M (1984) Dupuytren type fibromatoses. A clinicopathologic study of 62 cases. Acta Pathol Jpn 34: 991–1001PubMedGoogle Scholar
  30. Viljanto JA (1973) Dupuytren’s contracture: a review. Semin Arthritis Rheum 3: 155–176CrossRefGoogle Scholar
  31. Vossbeck G (1986) Zur Pathogenese der Palmarfibromatose (Morbus Dupuytren) - autoradiographische und elektronenmikroskopische Untersuchung. Medical dissertation, University of UlmGoogle Scholar
  32. Walker MA, Harley RA, Maize J, DeLustro F, LeRoy EC (1985) Mast cells and their degranulation in the Tsk mouse model of scleroderma. Proc Soc Exp Biol Med 180: 323–328PubMedGoogle Scholar
  33. Walker MA, Harley RA, LeRoy EC (1987) Inhibition of fibrosis in Tsk mice by blocking mast cell degranulation. J Rheumatol 14: 299–301PubMedGoogle Scholar
  34. Yost J, Winter T, Fett HC (1955) Dupuytrens contracture. A statistical study. Am J Surg 90: 568–571Google Scholar
  35. Zimmermann KW (1923) Der feinere Bau der Blutcapillaren. Z Anat Entwicklungsgesch 68: 29–109CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • W. Mohr
  • D. Wessinghage

There are no affiliations available

Personalised recommendations