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Enantioselective Catalysis with Chiral Metal Complexes

  • Conference paper
Stereoselective Synthesis

Abstract

Chemists have always been fascinated by the ability of enzymes to distinguish between two enantiomers or two enantiotopic sites in a molecule. For a long time, the almost perfect enantioselectivities observed in enzymatic reactions were considered beyond reach for non-biological catalysts. However, with the development of chiral rhodium-phosphine complexes for enantioselective hydrogenation [1] and the discovery of the proline-catalyzed Robinson annelation by Eder, Sauer, and Wiechert [2] and, independently, by Hajos and Parrish [3] around 1970, it became evident that high levels of enantioselectivity can also be achieved with synthetic catalysts. Since then, asymmetric catalysis has become a very active, rapidly growing area of research. As a result, a number of powerful synthetic catalysts have become available which allow the preparation of chiral compounds in high enantiomeric purity [4]. However, despite impressive achievements, the number of truly useful, generally applicable enantioselective catalysts is still limited. Thus, future research will continue to focus on the improvement of existing methods and on the search for new catalysts. In addition, the development of more rational guidelines for the design of enantioselective catalysts, which are based on structural and mechanistic considerations rather than intuition or purely empirical rules, will become more and more important.

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Authors and Affiliations

  1. Institut för Organische Chemie der Universität, St. Johanns-Ring 19, CH-4056, Basel, Switzerland

    A. Pfaltz

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  1. A. Pfaltz
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Editors and Affiliations

  1. Schering AG Berlin, D-13342, Berlin, Germany

    Eckhard Ottow , Klaus Schöllkopf  & Bernd-Günter Schulz ,  & 

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Pfaltz, A. (1994). Enantioselective Catalysis with Chiral Metal Complexes. In: Ottow, E., Schöllkopf, K., Schulz, BG. (eds) Stereoselective Synthesis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78496-5_2

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  • DOI: https://doi.org/10.1007/978-3-642-78496-5_2

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