In Vitro Systems for the Study and Propagation of Human Papillomaviruses
Papillomaviruses were first shown to be pathogenic agents by Shope and Hurst (1933) who identified them as the causative agent of infectious papillomatosis of cottontail rabbits. Later, Rous and Beard (1935) observed that benign papillomas of rabbits induced by this virus could progress to carcinomas. Attempts to develop systems for the propagation of papillomaviruses in vitro were unsuccessful and resulted in a dormancy of papillomavirus research until the 1970s. The late 1970s brought the beginning of molecular biology technology and the cloning of papillomavirus genomes. This allowed for the isolation of sufficient quantities of material to begin a systematic study of papillomaviruses. In the 1980s a correlation between papillomaviruses and human neoplastic lesions of the anogenital area led to a significant increase in interest in the study of these viruses.
KeywordsLeukemia Recombination Stratification Tamoxifen Hull
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