Pharmacological and Binding Evidence for Opioid Receptors on Vertebrate and Invertebrate Blood Cells
Current evidence indicates that opioid peptides, whose roles in the nervous system are well established, affect immunoactive cells (Smith and Blalock 1981; for review see Blalock 1989). The significance of this phenomenon is highlighted by the discovery that it applies to invertebrates as well as vertebrates (Leung and Stefano 1987; Stefano 1982, 1989). A search for stereoselective mechanisms mediating these neuropeptide activities has been under way for some time. Its results, though still incomplete, seem to indicate that in both groups of animals the complexity of ligand-receptor binding is greater than anticipated. The existing evidence for these parallels presented in this chapter, and in that by Janković and Marić, is based on pharmacological data as well as binding studies.
KeywordsOpioid Receptor Opioid Peptide Opioid Receptor Subtype Opioid Binding Opioid Binding Site
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