Abstract
An abundance of data has accumulated which strongly suggests that a linkage exists between the immune and neuroendocrine systems in vertebrates (Fischer and Falke 1984; Blalock 1985, 1989; Blalock and Smith 1985; Weigent and Blalock 1987; Dunn 1989; Smith 1991; Weigent and Blalock, Janković and Marić, both in this volume) and in invertebrates (Stefano 1989; Stefano et al. 1991). Many of the reports demonstrate that the two systems, in communicating with each other, produce and respond to similar signal molecules, i.e., cytokines and neuropeptides. The data also suggest that there is an interplay between these substances in the autoregulatory process of the immune system. More specifically, neuropeptides have been shown to effect immune responses through their influence on cytokine production and action. Conversely, cytokines are known to induce or influence the production of peptidergic messenger substances. The importance of these interactions is underscored by our recent demonstration that immune and nervous system interactions are conserved in organisms that are evolutionarily diverse from humans. For example, we have shown that opioids and monokines induce similar activities in immunocytes from a mollusc that is 500 million years divergent from humans (Fig. 1; Hughes et al. 1990; Stefano et al. 1991).
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Hughes, T.K., Chin, R. (1994). Interactions of Neuropeptides and Cytokines. In: Scharrer, B., Smith, E.M., Stefano, G.B. (eds) Neuropeptides and Immunoregulation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78480-4_7
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