Abstract
Hitherto, the development of spinal cord neurons has mainly been studied with classical histological staining techniques (His 1889; Ramon Y Cajal 1890; Retzius 1898) and with [3H]thymidine autoradiography (Sauer 1959; Sidman et al. 1959; Fujita 1964; Nornes and Das 1974; Altman and Bayer 1984). During the last two decades, different neuronal tracers were used to study the development of the ascending and descending fiber systems in the spinal cord. Until recently, the use of such tracers in mammals appeared to be restricted to the postnatal period because of difficulties in prenatal administration. The development of an intrauterine operation technique (De Beer et al. 1989) and a method for more accurate prenatal tracer application (see Lakke and Hinderink 1989) appear to offer new possibilities for investigating the embryonal development of fiber systems by means of neuronal tracers. So far, the results indicate the applicability of these techniques in developmental studies of the rat spinal cord fiber systems (Lakke and Hinderink 1989; Lakke and Marani 1991; Wessels et al. 1990). This particular tracing technique is used successfully in the present study.
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© 1993 Springer-Verlag Berlin Heidelberg
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Oudega, M., Lakke, E.A.J.F., Marani, E., Thomeer, R.T.W.M. (1993). A Survey of the Development of the Rat Spinal Cord. In: Development of the Rat Spinal Cord: Immuno- and Enzyme Histochemical Approaches. Advances in Anatomy Embryology and Cell Biology, vol 129. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78474-3_2
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DOI: https://doi.org/10.1007/978-3-642-78474-3_2
Publisher Name: Springer, Berlin, Heidelberg
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