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Expression of the β-Amyloid Precursor Protein Gene and the Pathogenesis of Alzheimer’s Disease

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Regulation of Gene Expression and Brain Function

Part of the book series: Basic and Clinical Aspects of Neuroscience ((BASIC,volume 6))

Abstract

Alzheimer’s disease (AD) is the commonest form of dementia, affecting about 5% of the population over 65 years of age and 20% of those aged 80 years. With the increasing number and proportion of elderly people, AD has become one of the major diseases in terms of prevalence, morbidity, mortality, and financial implications. As a consequence, investigation into its pathogenesis has become a health priority, since it is only in this way that effective symptomatic and curative therapies are likely to be developed.

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Authors and Affiliations

  1. University Department of Psychiatry, Warneford Hospital, Radcliffe Infirmary, Oxford, UK

    Paul J. Harrison

  2. Department of Neuropathology, Radcliffe Infirmary, Oxford, UK

    Paul J. Harrison

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  1. Department of Psychiatry Warneford Hospital, University of Oxford, OX3 7JX, Oxford, UK

    Paul J. Harrison

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© 1994 Springer-Verlag Berlin Heidelberg

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Harrison, P.J. (1994). Expression of the β-Amyloid Precursor Protein Gene and the Pathogenesis of Alzheimer’s Disease. In: Harrison, P.J. (eds) Regulation of Gene Expression and Brain Function. Basic and Clinical Aspects of Neuroscience, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78458-3_5

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  • DOI: https://doi.org/10.1007/978-3-642-78458-3_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-57156-8

  • Online ISBN: 978-3-642-78458-3

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