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Chromatin Structure, Gene Expression, and Nuclear Aluminum in Alzheimer’s Disease

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Regulation of Gene Expression and Brain Function

Part of the book series: Basic and Clinical Aspects of Neuroscience ((BASIC,volume 6))

Abstract

In eukaryotic nuclei, the expression of genes is a complex series of events in which information encoded in the DNA molecule is transcribed into ribonucleic acid (RNA) and translated into proteins essential for normal cellular function. The first step in the gene expression pathway appears to be an initial “loosening up” of local chromatin structure within the nucleus to create a chromatin configuration that enables specific DNA sequences to be recognized by basal transcription factors and RNA polymerase systems.

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Authors and Affiliations

  1. Tanz Neuroscience Building, Center for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada, M5 S IA8

    W. J. Lukiw, P. St. George-Hyslop & D. R. McLachlan

  2. Molecular Neurobiology, LSU Neuroscience Center, Louisiana State University School of Medicine, 2020 Gravier Street, Suite “B”, New Orleans, Louisiana, 70112-2234, USA

    W. J. Lukiw, P. St. George-Hyslop & D. R. McLachlan

Authors
  1. W. J. Lukiw
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  2. P. St. George-Hyslop
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  3. D. R. McLachlan
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Editors and Affiliations

  1. Department of Psychiatry Warneford Hospital, University of Oxford, OX3 7JX, Oxford, UK

    Paul J. Harrison

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© 1994 Springer-Verlag Berlin Heidelberg

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Lukiw, W.J., St. George-Hyslop, P., McLachlan, D.R. (1994). Chromatin Structure, Gene Expression, and Nuclear Aluminum in Alzheimer’s Disease. In: Harrison, P.J. (eds) Regulation of Gene Expression and Brain Function. Basic and Clinical Aspects of Neuroscience, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78458-3_4

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  • DOI: https://doi.org/10.1007/978-3-642-78458-3_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-57156-8

  • Online ISBN: 978-3-642-78458-3

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