Sorting and Intracellular Transport of RNA in Neurons: Regulation of Gene Expression at Synaptic Sites

  • Oswald Steward
  • Robin Kleiman
  • Gary Banker
Part of the Basic and Clinical Aspects of Neuroscience book series (BASIC, volume 6)


It has been recognized since the time of Cajal that different parts of the neuron are specialized for different functions; indeed, this is the basis for what Cajal called the “dynamic polarization of the neuron.” Axons are specialized for transmitting information over great distances, dendrites and cell bodies for receiving and integrating inputs from other cells, and synapses for communicating information from one neuron to the next. Each of these functional attributes depends upon two features: (1) the “molecular anatomy” of the neuron, which includes the composition and spatial distribution of receptors, channels, etc. in the neuronal plasma membrane and the intracellular distribution of organelles, second messenger systems, and enzyme systems; and (2) neuronal microstructure, i. e., the shape and spatial configuration of axons, dendrites, and the synaptic connections between them.


Neuronal Cell Body Signal Recognition Particle Axon Initial Segment Postsynaptic Site Synaptic Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Oswald Steward
    • 1
    • 2
  • Robin Kleiman
    • 1
    • 2
  • Gary Banker
    • 1
    • 2
  1. 1.Department of NeuroscienceUniversity of Virginia Health Sciences CenterCharlottesvilleUSA
  2. 2.Department of NeurosurgeryUniversity of Virginia Health Sciences CenterCharlottesvilleUSA

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