Abstract
Traditional neurochemical approaches to the study of the brain have been based upon detection and measurements of various aspects of proteins, including their distribution, abundance, and functional properties. With the advent of molecular biology, powerful tools are now available also for investigating the genes that encode these proteins. However, there is a considerable potential gulf in understanding between a gene and its protein product. This volume of Basic and Clinical Aspects of Neuroscience attempts to bridge this gap by highlighting gene expression, the pathway along which the genetic information contained in DNA is realized through the synthesis of proteins.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Armstrong RC, Montminy MR (1993) Transsynaptic control of gene expression. Annu Rev Neurosci 16: 17–29
Atwater JA, Wisdom R, Verma IM (1990) Regulated mRNA stability. Annu Rev Genet 24: 519–541
Bading H, Ginty DD, Greenberg ME (1993) Regulation of gene ex-pression in hippocampal neurons by direct calcium signalling pathways. Science 260: 181–1866.
Barton AJL, Pearson RCA, Najlerahim A, Harrison PJ (1993) Pre and post mortem influences on brain RNA. J Neurochem 61: 1–11
Chiasson B J, Hooper ML, Murphy PR, Robertson HA (1992) Anti- sense oligonucleotide eliminates in vivo expression of c-fos in mammalian brain. Eur J Pharmacol Mol Pharmacol 227: 451–453
Darnell J, Lodish H, Baltimore D (1990) Molecular cell biology. Freeman, San Francisco
Green MR (1991) Biochemical mechanisms of constitutive and regulated pre-mRNA splicing. Annu Rev Cell Biol 7: 559–599
Hanley MR (1988) Proto-oncogenes in the nervous system. Neuron 1: 175–182
Hargrove JL, Hulsey MG, Beale EG (1991) Problems and paradigms: the kinetics of mammalian gene expression. BioEssays 13: 667–674
Higgins CF, Peltz SW, Jacobson A (1992) Turnover of mRNA in prokaryotes and lower eukaryotes. Curr Opinion Genet Dev 2: 739–747
Lerea LS, McNamara JO (1993) Ionotropic glutamate receptor subtypes activate c-fos transcription by distinct calcium-requiring intracellular signalling pathways. Neuron 10: 31–41
Ross J (1989) The turnover of messenger RNA. Sci Am 260: 28–35
Sheng M, Greenberg ME (1990) The regulation of c-fos and other immediate early genes in the nervous system. Neuron 4: 477–485
Sudol M (1988) Expression of proto-oncogenes in neural tissues. Brain Res Rev 13: 391–403
Sutcliffe JG (1988) mRNA in the mammalian central nervous system. Annu Rev Neurosci 11:157–198
Zahlher AM, Neugebauer KM, Lane WS, Roth MB (1993) Distinct functions of SR proteins in alternative pre-mRNA splicing. Science 260: 219–222
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Harrison, P.J. (1994). Introduction: Gene Expression in the Brain. In: Harrison, P.J. (eds) Regulation of Gene Expression and Brain Function. Basic and Clinical Aspects of Neuroscience, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78458-3_1
Download citation
DOI: https://doi.org/10.1007/978-3-642-78458-3_1
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-57156-8
Online ISBN: 978-3-642-78458-3
eBook Packages: Springer Book Archive