Pharmacological Evidence for Full Agonist Activity of Abecarnil at Certain GABAA Receptors

  • M. Serra
  • C. A. Ghiani
  • C. Motzo
  • G. Biggio
Part of the Psychopharmacology Series book series (PSYCHOPHARM, volume 11)


It is now well established that the degree of activation of the central γ-aminobutyric acid type A (GABAA)-receptor complex is predictive of the pharmacological efficacy and clinical profile of the agonist ligands for benzodiazepine recognition sites (see review Biggio and Costa 1990; Biggio et al. 1992). Accordingly, anxiolytic and anticonvulsant drugs which enhance the function of GABAergic transmission with a low intrinsic activity are classified as “partial agonists,” i.e., compounds able to reduce the risk of tolerance, dependence, and unwanted effects attributed to “full agonists.”


GABAA Receptor Partial Agonist Full Agonist GABAergic Transmission GABAergic Synapse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • M. Serra
    • 1
  • C. A. Ghiani
    • 1
  • C. Motzo
    • 1
  • G. Biggio
    • 1
  1. 1.Department of Experimental Biology “Bernardo Loddo”University of CagliariItaly

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