Molecular Biology of Gamma-Aminobutyric Acid Type A/Benzodiazepine Receptors
Ligand-gated ion channels mediate large parts of the fast synaptic neurotransmission in the central nervous system (Dingledine et al. 1988). In recent years, mainly as a result of modern molecular-biology techniques, the understanding of the pharmacology, biochemistry, and electrophysiology of these channels has advanced greatly. The family of ligand-gated ion channels now comprises the molecularly related nicotinic acetylcholine receptors (AChR), the γ-aminobutyric acid type A receptors (GABAAR), the glycine receptors (GlyR), the serotonin receptor 5-hydroxytryptamin3 (5-HT3), and possibly some receptors of the glutamate receptor family (GluR; Betz 1990; Maricq et al. 1991; Monyer et al. 1992; Moriyoshi et al. 1991; Schofield et al. 1987).
KeywordsGABAA Receptor GABAAR Subunit GABAA Receptor Subtype GABAAR Subtype Brain GABAA Receptor
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