Factors and Receptors Involved in the Selection of B Lymphocytes Responding to T-Dependent Antigen
B lymphocyte responses to T-dependent (TD) antigens are characterized by a primary phase which tends to be restricted to the production of relatively low affinity antibodies of the immunoglobulin (Ig)M class and a secondary response where antibodies are of higher affinity and have switched to the use of downstream heavy chain genes. The so-called affinity maturation of TD responses has been attributed to a preference for preserving the better-fit antibodies available from the primary repertoire on secondary challenge or to recruitment de novo from a completely separate precursor pool. It is clear, however, that in contrast to the IgM antibody which dominates a primary challenge, switched antibodies from a secondary response exhibit an accumulation of mutations within the Ig variable regions.
KeywordsGerminal Center CD40 Ligand Follicular Dendritic Cell Immunol Today Nerve Growth Factor Receptor
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