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Effects of Alcohol on GABA-Mediated Neurotransmission

  • M. K. Ticku
  • A. K. Mehta
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 114)

Abstract

Ethanol is the oldest and most widely consumed and abused drug by our society. The exact mechanism of its action, including its ability to produce tolerance and withdrawal following chronic administration, is not yet known. Ethanol has been shown to affect a variety of neurotransmitters in the CNS. Recent evidence supports the notion that ethanol may produce many of its effects by modulating ligand-gated ion channels (mediated by receptors for GAB A, NMDA, 5-HT3) in the brain. The pharmacological profile of ethanol is very similar to that of benzodiazepines and barbiturates. These classes of drugs are anxiolytics, muscle relaxants, and anticonvulsants, and their chronic use results in tolerance (BELLEVILLE and FRAZER 1957). There also exists a cross-tolerance between ethanol and barbiturates, and ethanol and benzodiazepines. Furthermore, benzodiazepines and barbiturates are effective in the management of ethanol withdrawal syndromes (GOLDSTEIN 1973). These observations suggest that a common modulatory system may be involved at least in some of the pharmacological effects of these drugs. Since the GABAergic system is involved in the pharmacological actions of benzodiazepines and barbiturates (TICKU and RASTOGI 1980; OLSEN 1982; MAKSAY and TICKU 1985; BIGGIO et al. 1992), many investigations have focused on the effects of ethanol on GABAergic pathways.

Keywords

GABAA Receptor Chronic Ethanol Inverse Agonist Spinal Cord Neuron Audiogenic Seizure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1995

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  • M. K. Ticku
  • A. K. Mehta

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