Chemical and Biological Approaches to Catalytic Antibodies
A long-standing goal of biochemists is the design and synthesis of catalysts endowed with particular activities and properties. For example, one might create an enzyme that can degrade drugs into inactive metabolites as a treatment for drug overdoses or an enzyme that acts on a prodrug to unmask its therapeutically useful form. Yet another enzyme could target the cleavage of a specific tumor or virus protein that is vital for development of that tumor or virus thus acting as a therapeutic agent. Other traits, such as thermostability, chemical stability, and oxidative stability, can also be incorporated into such catalysts.
KeywordsKeyhole Limpet Hemocyanin Rate Acceleration Biological Approach Catalytic Antibody Uncatalyzed Reaction
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