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The Pharmacology of Monoclonal Antibodies pp 105–134Cite as

Humanization of Monoclonal Antibodies

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 113))

Abstract

Antibodies of predefined specificity have many potential uses in human therapy and diagnosis, and hybridoma technology (Koehler and Milstein 1975) has made possible the generation of virtually limitless amounts of such antibodies. Unfortunately, hybridoma proteins are more easily obtained from nonhuman, usually rodent, sources and the use of those antibodies in human subjects will be hindered by the patient’s immune system. The reduction of the immunogenicity in humans of xenogenic antibodies will make those molecules more efficacious reagents and various procedures for “humanizing” antibodies have been developed with this objective in mind.

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Authors
  1. G. E. Mark
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  2. E. A. Padlan
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Editor information

Editors and Affiliations

  1. Biopharmaceuticals Smith Kline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA, 19406-0939, USA

    Martin Rosenberg Ph.D. (Vice President and Director) (Vice President and Director)

  2. Department of Molecular Genetics, Smith Kline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA, 19406-0939, USA

    Gordon P. Moore Ph.D. (Director) (Director)

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© 1994 Springer-Verlag Berlin Heidelberg

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Mark, G.E., Padlan, E.A. (1994). Humanization of Monoclonal Antibodies. In: Rosenberg, M., Moore, G.P. (eds) The Pharmacology of Monoclonal Antibodies. Handbook of Experimental Pharmacology, vol 113. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78432-3_4

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  • DOI: https://doi.org/10.1007/978-3-642-78432-3_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78434-7

  • Online ISBN: 978-3-642-78432-3

  • eBook Packages: Springer Book Archive

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