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The Pharmacology of Monoclonal Antibodies pp 243–266Cite as

The Combinatorial Approach to Human Antibodies

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 113))

Abstract

The development of hybridoma technology 18 years ago appeared to promise antibodies for every application. Unfortunately, extension of the technique used for the production of mouse monoclonal antibodies (mAbs) to the production of human mAbs has proven to be difficult. Indeed, it is only within the past few years that advances in the field of molecular biology, coupled with the “combinatorial approach,” have allowed for the routine production of human mAbs. This chapter is meant to serve as an introduction to this new methodology, to review its success and to highlight future directions for the production of antibodies.

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Authors
  1. C. F. Barbas III
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Editors and Affiliations

  1. Biopharmaceuticals Smith Kline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA, 19406-0939, USA

    Martin Rosenberg Ph.D. (Vice President and Director) (Vice President and Director)

  2. Department of Molecular Genetics, Smith Kline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA, 19406-0939, USA

    Gordon P. Moore Ph.D. (Director) (Director)

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© 1994 Springer-Verlag Berlin Heidelberg

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Barbas, C.F. (1994). The Combinatorial Approach to Human Antibodies. In: Rosenberg, M., Moore, G.P. (eds) The Pharmacology of Monoclonal Antibodies. Handbook of Experimental Pharmacology, vol 113. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78432-3_10

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  • DOI: https://doi.org/10.1007/978-3-642-78432-3_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78434-7

  • Online ISBN: 978-3-642-78432-3

  • eBook Packages: Springer Book Archive

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