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Regulation of Drug Conjugate Production by Futile Cycling in Intact Cells

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Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 112))

Abstract

Conjugation of drugs and xenobiotics in liver and extrahepatie tissues is a complex process involving the availability of activated substrates such as uridine diphosphate (UDE)-glucuronic acid (Reinke et al. 1986) and adenosine 3’-phosphate-5’-phosphosulfate (PAPS) (Glazenburg et al. 1984), the uptake of substrates across various cellular membranes, and the formation and release of conjugated products (DeVries et al. 1985) as well as the activities of transferases and hydrolases (DeVries et al. 1985; El Mouelhi and Kauffman 1986; Schollhammer et al. 1975).

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Authors
  1. F. C. Kauffman
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Editors and Affiliations

  1. Laboratory for Cellular and Biochemical Toxicology College of Pharmacy, Rutgers University, Kilmer Campus 41 Gordon Road, Piscataway, NJ, 08854, USA

    Frederick C. Kauffman Ph.D. (Director) (Director)

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© 1994 Springer-Verlag Berlin Heidelberg

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Kauffman, F.C. (1994). Regulation of Drug Conjugate Production by Futile Cycling in Intact Cells. In: Kauffman, F.C. (eds) Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity. Handbook of Experimental Pharmacology, vol 112. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78429-3_9

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  • DOI: https://doi.org/10.1007/978-3-642-78429-3_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78431-6

  • Online ISBN: 978-3-642-78429-3

  • eBook Packages: Springer Book Archive

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