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Cofactor Supply as a Rate-Limiting Determinant of Hepatic Conjugation Reactions

  • L. A. Reinke
  • F. C. Kauffmann
  • R. G. Thurman
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 112)

Abstract

The metabolism of drugs, other xenobiotics, and endogenous compounds by conjugation is usually catalyzed by specific transferases; the notable exceptions are the non-enzymatic conjugation of highly reactive intermediates with glutathione (GSH) and the formation of acyl-linked glucuronides (reviewed in Chaps. 13 and 16 of this volume). Because of the important role of transferases in catalyzing conjugation reactions, these enzymes have been studied extensively, and the properties of the important conjugating enzymes are described in Chaps. 1–7.

Keywords

Perfuse Liver Inorganic Sulfate Sulfate Conjugation Hepatic Glutathione Buthionine Sulfoximine 
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© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • L. A. Reinke
  • F. C. Kauffmann
  • R. G. Thurman

There are no affiliations available

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